Calculating measures of biological interaction
Calculating measures of biological interaction
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DOI：
10.1007/s10654-005-7835-x
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发表时间：
2005-07-01
影响因子：
13.6
通讯作者：
Ahlbom, A
中科院分区：
文献类型：
--
作者：
Andersson, T;Alfredsson, L;Ahlbom, A
本期的一篇社论解释说，风险因素之间的生物相互作用程度是以相应疾病率与相加性的偏差来衡量的，而不是以例如与倍增性的偏差来衡量的。本文的目的是描述如何定义逻辑回归模型或考克斯回归模型，以产生评估生物相互作用所需的输出。我们还将演示如何对通用软件进行编程以提供此输出。最后，我们展示了如何将此输出用作Excel表格中的输入，该表格用于计算用于评估的生物相互作用的措施。
An editorial in this issue explains that the degree of biological interaction between risk factors is measured as the deviation from additivity by the corresponding disease rates and not for example as deviation from multiplicativity. It is the purpose of this article to describe how a logistic regression model, or a Cox regression model, can be defined in order to produce the output that is needed for assessment of biological interaction. We will also demonstrate how common software can be programmed to deliver this output. Finally, we show how this output can be used as input in an Excel sheet that is set up to calculate the measures of biological interaction to be used for the assessment.