Recognized spontaneous abortion in mid-pregnancy and patterns of pregnancy alcohol use
Recognized spontaneous abortion in mid-pregnancy and patterns of pregnancy alcohol use
复制标题
DOI：
10.1016/j.alcohol.2011.11.006
复制
发表时间：
2012-05-01
期刊：
影响因子：
2.3
通讯作者：
Hannigan, John H.
中科院分区：
文献类型：
--
作者：
Chiodo, Lisa M.;Bailey, Beth A.;Hannigan, John H.
怀孕期间饮酒是自然流产的一个潜在危险因素。先前的研究表明，怀孕期间大量饮酒与SAb发病率显著增加有关，但饮酒水平较低的结果却不一致。我们在一个高风险的市中心样本中检查了不同水平和模式的产前酒精消费与SAb之间的关系。我们假设较高的水平、暴饮模式和更频繁的饮酒与SAb的发病率增加有关。通过半结构化访谈，对302名非裔美国母亲的前瞻性子样本进行了评估，评估了自我报告的每种饮料类型的孕前饮酒量和怀孕期间重复饮酒量的数量和频率。使用逻辑回归评估产前酒精暴露与SAb之间的关系。在控制了各种潜在的混杂因素后，怀孕期间每天平均绝对酒精使用量与SAb之间存在显著的正相关。更频繁的饮酒也预示着SAb的发生：怀孕期间平均每周饮酒一天都会增加SAb的发病率。然而，与我们的假设相反，在控制混杂因素后，每天饮酒的量和酗酒的测量都与SAb没有显着相关。在这个低社会经济地位的非洲裔美国城市样本中，处于危险水平饮酒的妇女何时开始产前保健的差异可能低估了酒精对SAb的影响。一些怀孕期间的平均饮酒测量可能低估了SAb的摄入量，高估了SAb的风险，但其他避免这种限制的风险饮酒测量显示出与SAb相似的关系。确定孕妇的胎儿风险饮酒对提高干预措施的有效性至关重要，这些干预措施可降低饮酒风险水平并防止妊娠丢失。(C) 2012爱思唯尔公司版权所有。
Alcohol consumption during pregnancy is one potential risk factor for spontaneous abortion (SAb). Prior research suggested that heavy drinking during pregnancy was associated with significantly increased rates of SAb, but results for lower levels of drinking have been inconsistent. We examined the association between different levels and patterns of prenatal alcohol consumption and SAb in a high-risk inner-city sample. We hypothesized that higher levels, binge patterns, and more frequent drinking would be associated with increased rates of SAb. The quantity and frequency of self-reported pen-conceptional and repeated in-pregnancy maternal drinking volumes per beverage type were assessed with semi-structured interviews in a prospective subsample of 302 African-American mothers. Relations between various measures of prenatal alcohol exposure and SAb were assessed using logistic regression. After controlling for various potential confounders, there was a significant positive relation between average absolute alcohol use per day across pregnancy and SAb. Greater frequency of drinking episodes also predicted SAb: an average of even one day of drinking per week across pregnancy was associated with an increase in the incidence of SAb. However, contrary to our hypothesis, neither the amount of alcohol drunk per drinking day nor a measure of binge drinking was significantly related to SAb after controlling for confounders. Differences in when women who drank at risk levels initiated antenatal care may have under-estimated the impact of alcohol on SAb in this low-SES urban African-American sample. Some drinking measures averaged across pregnancy may have under-estimated consumption and overestimated risk of SAb, but other risk drinking measures that avoid this limitation show similar relations to SAb. Identifying fetal risk drinking in pregnant women is critical to increasing the effectiveness of interventions that reduce risk level alcohol consumption and protect from pregnancy loss. (C) 2012 Elsevier Inc. All rights reserved.