An FMRI study of self-regulatory control and conflict resolution in adolescents with bulimia nervosa.
An FMRI study of self-regulatory control and conflict resolution in adolescents with bulimia nervosa.
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DOI：
10.1176/appi.ajp.2011.11010094
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发表时间：
2011-11
期刊：
影响因子：
--
通讯作者：
Peterson BS
中科院分区：
文献类型：
--
作者：
Marsh R;Horga G;Wang Z;Wang P;Klahr KW;Berner LA;Walsh BT;Peterson BS
作者研究了调节神经性贪食症青少年自我调节能力和冲突解决的额纹状体系统的功能活动。功能性磁共振成像被用来比较血氧水平依赖性反应在18名女性青少年与神经性贪食症和18名健康女性年龄匹配的科目在性能西蒙空间不相容的任务。贝叶斯分析被用来比较两组在正确的反应冲突刺激的大脑激活模式，并探讨影响的先行刺激的背景下，在自我调节和冲突解决的群体差异。患有和没有神经性贪食症的青少年在这项任务中表现相似。在冲突试验的正确反应中，与健康对照组相比，患有神经性贪食症的青少年的额纹状体回路包括右下外侧和背外侧前额叶皮质和壳核未能达到相同的激活程度。相反，在左侧额下回以及包括后扣带回和上级额回的神经系统中观察到失活。皮质区和纹状体区的组差异驱动的差异反应的刺激之前的冲突和非冲突的刺激，分别。当从事必要的自我调节控制过程，以解决冲突，青少年与神经性贪食症显示异常模式的激活额纹状体和默认模式系统。他们对先行刺激的异常处理使他们的大脑对冲突的反应与健康对照受试者不同，特别是在额叶区域。据推测，额纹状体系统前部的功能紊乱可能会使进食行为从调节控制中释放出来，从而使神经性贪食症特征性的消耗增肥食物和避免体重增加的冲突欲望永久化。
The authors examined functional activity in the frontostriatal systems that mediate self-regulatory capacities and conflict resolution in adolescents with bulimia nervosa. Functional magnetic resonance imaging was used to compare blood-oxygen-level-dependent response in 18 female adolescents with bulimia nervosa and 18 healthy female age-matched subjects during performance on a Simon spatial incompatibility task. Bayesian analyses were used to compare the two groups on patterns of brain activation during correct responses to conflict stimuli and to explore the effects of antecedent stimulus context on group differences in self-regulation and conflict resolution. Adolescents with and without bulimia nervosa performed similarly on the task. During correct responses in conflict trials, frontostriatal circuits—including the right inferolateral and dorsolateral prefrontal cortices and putamen—failed to activate to the same degree in adolescents with bulimia nervosa as in healthy comparison subjects. Instead, deactivation was seen in the left inferior frontal gyrus as well as a neural system encompassing the posterior cingulate cortex and superior frontal gyrus. Group differences in cortical and striatal regions were driven by the differential responses to stimuli preceded by conflict and nonconflict stimuli, respectively. When engaging the self-regulatory control processes necessary to resolve conflict, adolescents with bulimia nervosa displayed abnormal patterns of activation in frontostriatal and default-mode systems. Their abnormal processing of the antecedent stimulus context conditioned their brain response to conflict differently from that of healthy comparison subjects, specifically in frontal regions. It is suspected that functional disturbances in frontal portions of frontostriatal systems may release feeding behaviors from regulatory control, thereby perpetuating the conflicting desires to consume fattening foods and avoid weight gain that characterize bulimia nervosa.
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影响因子：
5.7
作者：
Thirion, Bertrand;Pinel, Philippe;Poline, Jean-Baptiste
通讯作者：
Poline, Jean-Baptiste
影响因子：
--
作者：
Marsh, Rachel;Steinglass, Joanna E.;Peterson, Bradley S.
通讯作者：
Peterson, Bradley S.
影响因子：
5.3
作者：
Bravender, T.;Bryant-Waugh, R.;Zucker, N.
通讯作者：
Zucker, N.
DOI：
10.1037//0096-1523.28.6.1345
发表时间：
2002-12-01
影响因子：
2.1
作者：
Stürmer, B;Leuthold, H;Sommer, W
通讯作者：
Sommer, W
影响因子：
5.7
作者：
Neumann, J;Lohmann, G
通讯作者：
Lohmann, G