First in vivo use of a capacitive micromachined ultrasound transducer array-based imaging and ablation catheter.
First in vivo use of a capacitive micromachined ultrasound transducer array-based imaging and ablation catheter.
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DOI：
10.7863/jum.2012.31.2.247
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发表时间：
2012-02
期刊：
影响因子：
--
通讯作者：
Sahn DJ
中科院分区：
文献类型：
--
作者：
Stephens DN;Truong UT;Nikoozadeh A;Oralkan O;Seo CH;Cannata J;Dentinger A;Thomenius K;de la Rama A;Nguyen T;Lin F;Khuri-Yakub P;Mahajan A;Shivkumar K;O'Donnell M;Sahn DJ
主要目的是首次在体内测试由微线性电容微机械超声换能器（ML-CMUT）成像阵列构建的新型多功能心内超声心动图（ICE）导管的一般操作。其次，我们检查了该导管与电解剖标测 (EAM) 引导以及作为射频消融 (RFA) 导管的兼容性。在 RFA 期间同时从心内膜内获得初步热应变成像 (TSI) 衍生的温度数据，以显示直接消融引导程序的可行性。新型 9F 前瞻性 ICE 导管采用 3 种互补技术构建：带有定制电子阵列缓冲器的 CMUT 成像阵列、用于 EAM 引导的导管表面电极以及允许同时进行 TSI 和 RFA 的特殊消融尖端。对带有 5 个 CMUT 导管的 5 个麻醉猪模型进行了体内成像研究。 ML-CMUT ICE 导管可提供高于 8 MHz 的高分辨率实时宽带二维 (2D) 图像，并且能够进行 RFA 和 EAM 引导。虽然24阵元阵列孔径尺寸仅为1.5毫米，但成像穿透深度大于30毫米。专门设计的超声兼容金属化塑料尖端允许在消融过程中同时成像并直接采集组织消融温度的 TSI 数据。后处理分析显示 TSI 和温度之间存在一阶相关性，从而允许在特定心肌消融部位早期形成温度-时间关系。多功能前瞻性 ML-CMUT ICE 导管具有同步心内引导、超声成像和 RFA 功能，可能为改善介入消融手术提供新方法。
The primary objective was to test in vivo for the first time the general operation of a new multifunctional intracardiac echocardiography (ICE) catheter constructed with a microlinear capacitive micromachined ultrasound transducer (ML-CMUT) imaging array. Secondarily, we examined the compatibility of this catheter with electroanatomic mapping (EAM) guidance and also as a radiofrequency ablation (RFA) catheter. Preliminary thermal strain imaging (TSI)-derived temperature data were obtained from within the endocardium simultaneously during RFA to show the feasibility of direct ablation guidance procedures. The new 9F forward-looking ICE catheter was constructed with 3 complementary technologies: a CMUT imaging array with a custom electronic array buffer, catheter surface electrodes for EAM guidance, and a special ablation tip, that permits simultaneous TSI and RFA. In vivo imaging studies of 5 anesthetized porcine models with 5 CMUT catheters were performed. The ML-CMUT ICE catheter provided high-resolution real-time wideband 2-dimensional (2D) images at greater than 8 MHz and is capable of both RFA and EAM guidance. Although the 24-element array aperture dimension is only 1.5 mm, the imaging depth of penetration is greater than 30 mm. The specially designed ultrasound-compatible metalized plastic tip allowed simultaneous imaging during ablation and direct acquisition of TSI data for tissue ablation temperatures. Postprocessing analysis showed a first-order correlation between TSI and temperature, permitting early development temperature-time relationships at specific myocardial ablation sites. Multifunctional forward-looking ML-CMUT ICE catheters, with simultaneous intracardiac guidance, ultrasound imaging, and RFA, may offer a new means to improve interventional ablation procedures.
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作者：
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通讯作者：
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DOI：
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发表时间：
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DOI：
10.1161/circep.109.872093
发表时间：
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期刊：
Circulation. Arrhythmia and electrophysiology
影响因子：
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