Identification of Key Genes and Pathways Associated With Irradiation in Breast Cancer Tissue and Breast Cancer Cell Lines
Identification of Key Genes and Pathways Associated With Irradiation in Breast Cancer Tissue and Breast Cancer Cell Lines
复制标题
乳腺癌组织和乳腺癌细胞系中与辐射相关的关键基因和通路的鉴定
DOI：
10.1177/1559325820931252
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发表时间：
2020-04-01
期刊：
影响因子：
2.5
通讯作者：
Fan, Saijun
中科院分区：
文献类型：
--
作者：
Zhu, Changchun;Ge, Chang;Fan, Saijun
放射治疗主要是乳腺癌的传统治疗方法，然而，乳腺癌中与放射相关的关键基因和途径尚不清楚。本研究旨在探讨乳腺癌放疗前后mRNA表达的变化。基因表达数据集（GSE 59733）从Gene Expression Omnibus数据库下载。根据|log（2）FC（倍数变化）|>= 1，且错误发现率经调整P值
Radiotherapy is mainly a traditional treatment for breast cancer; however, the key genes and pathways in breast cancer associated with irradiation are not clear. In this study, we aimed to explore the messenger RNA expression changes between preradiation and postradiation breast cancer. The gene expression data set (GSE59733) was downloaded from Gene Expression Omnibus database. According to |log(2)FC (fold change) | >= 1 and with false discovery rate adjustedPvalue