Pregnancy and postpartum antidepressant use moderates the effects of sleep on depression.
Pregnancy and postpartum antidepressant use moderates the effects of sleep on depression.
复制标题
怀孕和产后使用抗抑郁药可以减轻睡眠对抑郁症的影响。
DOI：
10.1007/s00737-017-0726-9
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
O'Grady,KevinE
中科院分区：
文献类型：
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作者：
Stone,KristenC;Salisbury,AmyL;Miller-Loncar,CynthiaL;Mattera,JenniferA;Battle,CynthiaL;Johnsen,DawnM;O'Grady,KevinE
This study examined the course of antidepressant use, sleep quality, and depression severity from pregnancy through 6-month postpartum in women with and without a depressive disorder during pregnancy. Women (N= 215) were interviewed during pregnancy, 1- and 6-month postpartum. Mixed linear models were used to examine the longitudinal course and inter-relationships for the time-varying variables of antidepressant use, subjective sleep quality, and depression severity. Pregnant women with a depressive disorder who did not use antidepressants had more variable depression severity over time with improvements in depression severity by 6-month postpartum. In contrast, the depression severity of their medicated counterparts remained stable and high throughout. Pregnant women without a depressive disorder had worse sleep quality when using antidepressants compared with when they were not. Antidepressant use significantly strengthened the magnitude of the effect of sleep quality on depression severity in women with a depressive disorder during pregnancy. When prenatally depressed women use antidepressants, their sleep disturbance is more highly linked to depression severity than when they do not. Furthermore, antidepressants are not adequately treating the sleep disturbance of these women or their remitted counterparts, leaving both groups vulnerable to significant negative mental and physical health outcomes.
