Prepulse inhibition in HIV-1 gp120 transgenic mice after withdrawal from chronic methamphetamine.
Prepulse inhibition in HIV-1 gp120 transgenic mice after withdrawal from chronic methamphetamine.
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DOI：
10.1097/fbp.0000000000000012
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发表时间：
2014-02
影响因子：
1.6
通讯作者：
Translational Methamphetamine AIDS Research Center (TMARC) Group
中科院分区：
文献类型：
--
作者：
Henry BL;Geyer MA;Buell MR;Perry W;Young JW;Minassian A;Translational Methamphetamine AIDS Research Center (TMARC) Group
艾滋病毒感染经常与甲基苯丙胺（METH）依赖共病。这两个因素都与抑制功能的损害有关，即使在戒断药物后也会继续存在。前脉冲抑制（PPI），感觉运动门控措施的缺陷，是由急性兴奋剂管理，但艾滋病毒和慢性METH暴露对PPI的综合影响没有得到很好的表征。我们定量表达HIV-1 gp 120包膜蛋白（gp 120 tg）的小鼠和野生型（WT）同窝小鼠的基线声惊吓和PPI;此后，我们给予METH或溶媒的慢性方案，并在停药7天后测试惊吓和PPI。我们假设，与溶剂处理的WT或gp 120 tg动物相比，METH处理的gp 120 tg小鼠将表现出PPI缺陷。在METH给药前，与雌性WT小鼠相比，未用药的雌性gp 120 tg小鼠表现出PPI降低，而与其他组相比，雄性gp 120 tg小鼠表现出惊吓增加。停药后，没有观察到一致的基因型效应，但与媒介物相比，METH治疗的小鼠表现出PPI增加，与先前报道的急性METH诱导的PPI缺陷相反。总之，PPI损害艾滋病毒可能取决于因素，如性别，而PPI的变化后METH停药可能取决于药物暴露的数量和持续时间。
HIV infection is frequently comorbid with methamphetamine (METH) dependence. Both factors are associated with impairment in inhibitory function that continues even after abstinence from the drug. Deficits in prepulse inhibition (PPI), a measure of sensorimotor gating, are induced by acute stimulant administration, but the combined effect of HIV and chronic METH exposure on PPI is not well characterized. We quantified baseline acoustic startle and PPI in mice expressing the HIV-1 gp120 envelope protein (gp120tg) and in wild-type (WT) littermates; thereafter, we administered a chronic regimen of METH or vehicle and tested startle and PPI after 7 days of drug withdrawal. We hypothesized that METH-treated gp120tg mice would exhibit PPI deficits compared with vehicle-treated WT or gp120tg animals. Before METH administration, drug-naive female gp120tg mice exhibited decreased PPI compared with female WT mice, whereas male gp120tg mice exhibited increased startle compared with other groups. After drug withdrawal, no consistent genotype effect was observed, but METH-treated mice exhibited increased PPI compared with vehicle, in contrast to previous reports of acute METH-induced PPI deficits. In summary, PPI impairment in HIV could depend on factors such as sex, whereas changes in PPI following METH withdrawal may depend on the quantity and duration of drug exposure.