ICG Fluorescence Technique for the Detection of Sentinel Lymph Nodes in Breast Cancer: Results of a Prospective Open-label Clinical Trial
ICG Fluorescence Technique for the Detection of Sentinel Lymph Nodes in Breast Cancer: Results of a Prospective Open-label Clinical Trial
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DOI：
10.1055/s-0035-1557905
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发表时间：
2015-09-01
影响因子：
2.7
通讯作者：
Wallwiener, D.
中科院分区：
文献类型：
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作者：
Grischke, E. -M.;Roehm, C.;Wallwiener, D.
前哨淋巴结（SLN）的检测是评估乳腺癌腋窝淋巴结状态的标准程序。除了已知和已建立的程序，如蓝色染料法和闪烁法，本研究还调查了基于使用荧光染料吲哚菁绿（ICG）的方法的功效。患者和方法：对126例经穿刺活检证实的乳腺癌患者在手术切除SLN过程中进行了研究。除了用锝和闪光法进行SLN标记外，还使用吲哚菁绿（ICG）代替标准蓝色染料进行个体内比较。结果：闪烁显像检出率96%；ICG的检出率略低于89%。发现身体质量指数（BMI） bbb40是荧光法的限制因素。对与使用ICG荧光染料相关的潜在毒性的调查显示，没有全身甚至局部副作用。发现荧光法比闪烁法要便宜得多。结论：ICG荧光技术与蓝染法、荧光显像法相比，在临床应用中是一种有效可行的SLN检测方法。
Introduction: Detection of sentinel lymph nodes (SLN) is the standard procedure to evaluate axillary lymph node status in breast cancer. In addition to known and established procedures such as the blue dye method and scintigraphy, this study investigated the efficacy of a method based on use of the fluorescent dye indocyanine green (ICG).Patients and Method: A total of 126 women with breast cancer histologically verified by punch biopsy were studied during surgical removal of SLN. In addition to SLN marking with technetium and scintigraphy, intra-individual comparison was done using indocyanine green (ICG) for marking instead of the standard blue dye.Results: Scintigraphy had a detection rate of 96%; the detection rate with ICG was just under 89%. A body mass index (BMI) > 40 was found to be a limiting factor for the fluorescent method. Investigation into potential toxicities associated with the use of the fluorescent dye ICG revealed no systemic or even local side effects. The fluorescent method was found to be significantly less expensive than the scintigraphy method.Conclusion: The ICG fluorescence technique for the detection of SLN was found to be a valid and feasible method in clinical practice when compared directly with the blue dye method and scintigraphy.