Fate of manganese associated with the inhalation of welding fumes: Potential neurological effects
Fate of manganese associated with the inhalation of welding fumes: Potential neurological effects
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DOI：
10.1016/j.neuro.2005.09.001
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发表时间：
2006-05-01
期刊：
影响因子：
3.4
通讯作者：
Lucchini, Roberto
中科院分区：
文献类型：
--
作者：
Antonini, James M.;Santaimaria, Annette B.;Lucchini, Roberto
焊接烟尘是由不同金属组成的复杂混合物。大多数焊接烟尘含有少量的锰。职业卫生官员对接触焊接烟雾中的锰可能对神经系统产生的影响表示关注。人们对吸入后与焊接颗粒中其他金属络合的锰的命运知之甚少。取决于焊接工艺和焊条的组成，锰可以以不同的氧化态存在并且具有不同的溶解度特性。这些差异可能会影响锰的生物反应后，吸入焊接烟雾。据报告，由于在通风不良的区域工作，焊工暴露于高浓度的含锰焊接烟雾中，出现锰中毒和相关的神经症状。然而，问题仍然是长期暴露在低水平焊接烟雾中的焊工是否有患神经系统疾病的风险。在大多数情况下，问题仍然没有答案。仍然缺乏足够的科学报告，焊工谁遭受显着的神经毒性，因此有必要进行精心设计的流行病学研究，结合联合收割机完整的信息，焊工的职业暴露与神经毒性的行为和生化终点。爱思唯尔公司出版
Welding fumes are a complex mixture composed of different metals. Most welding fumes contain a small percentage of manganese. There is an emerging concern among occupational health officials about the potential neurological effects associated with the exposure to manganese in welding fumes. Little is known about the fate of manganese that is complexed with other metals in the welding particles after inhalation. Depending on the welding process and the composition of the welding electrode, manganese may be present in different oxidation states and have different solubility properties. These differences may affect the biological responses to manganese after the inhalation of welding fumes. Manganese intoxication and the associated neurological symptoms have been reported in individual cases of welders who have been exposed to high concentrations of manganese-containing welding fumes due to work in poorly ventilated areas. However, the question remains as to whether welders who are exposed to low levels of welding fumes over long periods of time are at risk for the development of neurological diseases. For the most part, questions remain unanswered. There is still paucity of adequate scientific reports on welders who suffered significant neurotoxicity, hence there is a need for well-designed epidemiology studies that combine complete information on the occupational exposure of welders with both behavioral and biochemical endpoints of neurotoxicity. Published by Elsevier Inc.