Krüppel-like factors in cancer progression: three fingers on the steering wheel.
Krüppel-like factors in cancer progression: three fingers on the steering wheel.
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DOI：
10.18632/oncotarget.1456
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发表时间：
2014-01-15
期刊：
影响因子：
--
通讯作者：
Pauwels P
中科院分区：
文献类型：
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作者：
Limame R;Op de Beeck K;Lardon F;De Wever O;Pauwels P
Krüppel样因子（KLF）是一个高度保守的锌指转录因子家族，参与细胞增殖、凋亡、分化、迁移和多能性等多种细胞过程。在过去的几年中，关于它们在不同人类癌症中的作用和放松管制的证据已经出现。本文将讨论目前的知识Krüppel样转录上皮间质转化（EMT），侵袭和转移，重点是上皮癌生物学和多能性的广泛接口。此外，由于KLF能够介导不同的结果，因此将突出细胞和微环境背景的重要影响。最后，我们试图整合不同的发现KLF功能EMT和干细胞生物学FT在目前的模型中的细胞可塑性作为一种工具，成功转移性传播。
Krüppel-like factors (KLFs) comprise a highly conserved family of zinc finger transcription factors, that are involved in a plethora of cellular processes, ranging from proliferation and apoptosis to differentiation, migration and pluripotency. During the last few years, evidence on their role and deregulation in different human cancers has been emerging. This review will discuss current knowledge on Krüppel-like transcription in the epithelial-mesenchymal transition (EMT), invasion and metastasis, with a focus on epithelial cancer biology and the extensive interface with pluripotency. Furthermore, as KLFs are able to mediate different outcomes, important influences of the cellular and microenvironmental context will be highlighted. Finally, we attempt to integrate diverse findings on KLF functions in EMT and stem cell biology to ft in the current model of cellular plasticity as a tool for successful metastatic dissemination.