Parametric effects of transcranial alternating current stimulation on multitasking performance
Parametric effects of transcranial alternating current stimulation on multitasking performance
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DOI：
10.1016/j.brs.2018.10.010
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发表时间：
2019-01-01
影响因子：
7.7
通讯作者：
Gazzaley, Adam
中科院分区：
文献类型：
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作者：
Hsu, Wan-Yu;Zanto, Theodore P.;Gazzaley, Adam
背景资料：我们以前已经证明，经颅交流电刺激（tACS）可以产生积极的影响，多任务的性能和相关的神经生理措施时，它与反相θ波带刺激双侧前额叶皮层（PFC）和短（1分钟）会话间间隔（ISI）。然而，目前尚不清楚如何改变刺激的相位和ISI的持续时间可能会影响积极的tACS效应。在这里，我们通过操纵这两个刺激参数来研究tACS参数在产生性能改善中的作用（即相位和ISI）。采用同相刺激+ 1 min ISI重复双侧PFC θ-tACS（实验1）和反相刺激+5-min ISI（实验2），同时参与者进行多任务挑战，伴随着脑电图（EEG）数据的收集。与对照组相比，同相刺激+ 1分钟ISI显示多任务执行的增强，以及后部α（8-12 Hz）和β（13-30 Hz）活动的调制。然而，反复会议的反相tACS + 5分钟ISI没有产生显着的增强多任务的性能，也没有变化，神经振荡活动相比，控制group.Conclusion：结果显示，以前报道的积极tACS的影响，多任务的性能不受操纵的相位电流极性。然而，改变刺激方案的ISI消除了先前观察到的性能改进。总之，这些结果强调了刺激方案对认知功能和神经振荡产生积极tACS效应的重要性。(C)2018爱思唯尔公司All rights reserved.
Background: We have previously demonstrated that transcranial alternating current stimulation (tACS) can generate positive effects on multitasking performance and associated neurophysiological measures when it is applied with anti-phase theta band stimulation across bilateral prefrontal cortex (PFC) and a short (1-min) inter-session interval (ISI). However, it is unclear how altering the phase of stimulation and the duration of the ISI might impact positive tACS effects. Here, we investigated the role of tACS parameters in engendering performance improvements by manipulating these two stimulation parameters (i.e. phase and ISI) in two experiments.Methods: Repetitive sessions of bilateral PFC theta-tACS were applied with in-phase stimulation + 1-min ISI (experiment 1) and anti-phase stimulation + 5-min ISI (experiment 2) while participants were engaged in a multitasking challenge accompanied by electroencephalography (EEG) data collection.Results: Compared to the control group, in-phase stimulation + 1-min ISI showed an enhancement of multitasking performance coupled with a modulation of posterior alpha (8-12 Hz) and beta (13-30 Hz) activities. However, repetitive sessions of anti-phase tACS + 5-min ISI did not generate significant enhancement in multitasking performance, nor changes in neural oscillatory activities compared to the control group.Conclusion: The results revealed that the previous reported positive tACS effects on multitasking performance are not affected by manipulating the phase of current polarity. Yet, changing the ISI of the stimulation protocol eliminated the previous observed performance improvements. Taken together, these results stress the importance of stimulation protocol for generating positive tACS effects on cognitive function and neural oscillations. (C) 2018 Elsevier Inc. All rights reserved.