Autophagy deficiency boosts the production of kojic acid in the filamentous fungus <i>Aspergillus oryzae</i>
Autophagy deficiency boosts the production of kojic acid in the filamentous fungus <i>Aspergillus oryzae</i>
复制标题
自噬缺陷促进丝状真菌米曲霉中曲酸的产生
DOI：
10.1093/bbb/zbab175
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Arioka Manabu
中科院分区：
文献类型：
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作者：
Chen Junlin;Arioka Manabu
我们发现，参与曲酸（KA）生物合成的基因，kojA，kojR和kojT的表达在米曲霉自噬缺陷突变体中高度升高。在协议中，KA生产大大增加，在这些突变体。在自噬突变体中观察到KojR（一种转录因子）在饥饿前的核转位，这解释了KA产量增加的原因。
We found that the expression of genes involved in kojic acid (KA) biosynthesis,kojA, kojR, andkojT, was highly elevated in theAspergillus oryzaeautophagy-deficient mutants. In agreement, KA production was much increased in these mutants. Nuclear translocation of KojR, a transcription factor, was observed in the autophagy mutants before they were starved, explaining why KA production was boosted.