Hanging in the balance: natural killer cell recognition of target cells.
Hanging in the balance: natural killer cell recognition of target cells.
复制标题
悬而未决：自然杀伤细胞对靶细胞的识别。
DOI：
10.1016/1074-5521(95)90258-9
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发表时间：
1995
影响因子：
--
通讯作者：
Brissette-Storkus,CS
中科院分区：
文献类型：
--
作者：
Chambers,WH;Brissette-Storkus,CS
自然杀伤（NK）细胞直接杀死某些肿瘤细胞和病毒感染的细胞。直到最近，人们对它们如何识别目标知之甚少。现在，已经鉴定了几种候选NK受体，其中一些可能具有碳水化合物配体。一些受体传递正信号，另一些则传递负信号。因此，NK细胞似乎平衡了许多不同的输入，以决定是否杀死目标。
Natural killer (NK) cells kill certain tumor cells and virus-infected cells directly. Until recently, little was known about how they recognize their targets. Now, several candidate NK receptors have been identified, some of which may have carbohydrate ligands. Some of the receptors deliver positive signals, others negative signals. Thus NK cells seem to balance many different inputs to decide whether to kill a target.