Increased accuracy of ligand sensing by receptor internalization
Increased accuracy of ligand sensing by receptor internalization
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DOI：
10.1103/physreve.81.021909
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发表时间：
2010-02-01
影响因子：
2.4
通讯作者：
Endres, Robert G.
中科院分区：
文献类型：
--
作者：
Aquino, Gerardo;Endres, Robert G.
许多类型的细胞可以用细胞表面受体以极高的准确度感测外部配体浓度。有趣的是，配体结合的受体通常被内化，这一过程也称为受体介导的内吞作用。虽然内化涉及细胞生命的大量重要功能，但最近还建议增加感测配体的准确性，因为相同配体分子的过度计数减少。在这里，我们表明，通过扩展简单的配体-受体模型的平衡热力学，内化增加的准确性，细胞可以测量配体浓度在外部环境中。与真实的受体的实验速率的比较表明，我们的模型确实具有生物学意义。
Many types of cells can sense external ligand concentrations with cell-surface receptors at extremely high accuracy. Interestingly, ligand-bound receptors are often internalized, a process also known as receptor-mediated endocytosis. While internalization is involved in a vast number of important functions for the life of a cell, it was recently also suggested to increase the accuracy of sensing ligand as the overcounting of the same ligand molecules is reduced. Here we show, by extending simple ligand-receptor models to out-of-equilibrium thermodynamics, that internalization increases the accuracy with which cells can measure ligand concentrations in the external environment. Comparison with experimental rates of real receptors demonstrates that our model has indeed biological significance.