Changes in drinking status, serious illness and mortality
Changes in drinking status, serious illness and mortality
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DOI：
10.15288/jsa.2003.64.278
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发表时间：
2003-03-01
期刊：
影响因子：
--
通讯作者：
Bostrom, A
中科院分区：
文献类型：
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作者：
Fillmore, KM;Kerr, WC;Bostrom, A
目的：我们在一项两个测量点的前瞻性研究中研究了饮酒和戒酒与全因死亡率的关系，以评估健康人和重病患者饮酒变化与稳定的重要性。方法：国家健康和营养调查 I (NHANES I) 以及对第一次测量 (1971-74) 时存活到第二次测量 (1982-84) 的男性和女性 (22-49 岁和 50+) 的随访，并在死亡记录中跟踪 10 年 (1993 年)。考克斯比例风险模型评估了患有和未患有严重疾病的人。结果：我们发现，一贯不饮酒者的死亡风险并未升高，但一贯大量饮酒者在男性中的全因风险较高。戒酒者群体的死亡风险存在显着差异，而这些差异与疾病有关。以前戒酒的新饮酒者并没有提高长寿的机会。酗酒的男性减少饮酒量会增加他们的生存机会。结论：戒酒本身并不是全因死亡的危险因素，但大量饮酒是男性的危险因素。曾经戒酒的人开始饮酒并不能提高生存机会。减少酗酒男性的饮酒量可以提高生存机会。
Objective: We studied the relationship of drinking and abstaining with all-cause mortality in a two-measurement-point prospective study to assess the importance of drinking change versus stability among the healthy and seriously ill. Method: The National Health and Nutrition Examination Survey I (NHANES I) and follow-up of men and women (age 22-49 and 50+) at first measurement (1971-74) who survived until second measurement (1982-84) were followed in death records for 10 years (1993). Cox proportional hazards models evaluated those with and without serious illness. Results: We found no elevated mortality risk for consistent never drinkers, but consistent heavier drinkers were at higher all-cause risk among men. Groups of abstainers significantly differed for mortality risk, and illness was implicated in these differences. New drinkers who formerly abstained did not improve their chances for longevity. Heavier drinking men who decreased consumption increased their chances for survival. Conclusions: Abstinence per se is not a risk factor for all-cause mortality, but heavier drinking is a risk factor among men. Adoption of drinking among former abstainers does not improve chances for survival. Reduction in consumption among heavier drinking men improves chances for survival.