Effect of hormonal contraceptives on lipid profile and the risk indices for cardiovascular disease in a Ghanaian community.
Effect of hormonal contraceptives on lipid profile and the risk indices for cardiovascular disease in a Ghanaian community.
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激素避孕药对加纳社区血脂状况和心血管疾病风险指数的影响。
DOI：
10.2147/ijwh.s59852
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Amoah AG
中科院分区：
文献类型：
--
作者：
Asare GA;Santa S;Ngala RA;Asiedu B;Afriyie D;Amoah AG
激素避孕药（HC）已被证明可以改变具有不同血脂异常模式和心血管（CV）风险的各种人群的血脂谱。该研究旨在确定加纳队列的血脂谱模式和CV风险。进行了有目的的随机抽样。47例和19例分别使用口服避孕药（OC）和注射避孕药（IC）; 5例使用皮下埋植剂。24名非使用者作为对照。生物人口学和血脂谱进行了测定。测定总胆固醇（TC）、高密度脂蛋白胆固醇（HDLC）、低密度脂蛋白胆固醇（LDLC）和极低密度脂蛋白胆固醇（VLDLC）。计算卡斯泰利指数I和II。HC组和对照组之间的平均年龄差异不显著。然而，舒张压（BP）差异显著（P=0.006）。OC组和IC组的体重指数（BMI）与对照组相比差异有统计学意义（分别为P=0.003和P=0.008）。对照组和病例组TC分别为3.35±0.62 mmol/L和4.07±0.91 mmol/L（P=0.002）。对照组和病例组的LDLC水平分别为1.74±0.57 mmol/L和2.38±0.84 mmol/L（P=0.003）。卡斯泰利指数I（TC/HDL C）和II（LDL C/HDL C）在对照组和OC组之间差异有统计学意义（分别为P=0.026和P=0.014）。斯皮尔曼rho相关性显示，HC使用对TG（P=0.026）、TC（P=0.000）、LDLC（P=0.004）和VLDLC（P=0.026）随时间推移的显著影响。HC使用与BMI、舒张压、TC、LDLC和卡斯泰利指数I和II显著增加相关。这些变化在CV疾病的发展中具有潜在风险。
Hormonal contraceptives (HCs) have been shown to alter lipid profile among various population groups with different patterns of dyslipidemia and cardiovascular (CV) risk. The study aimed at determining the lipid profile pattern and CV risk in a Ghanaian cohort. Purposive random sampling was done. Forty-seven and 19 cases were on oral contraceptives (OCs) and injectable contraceptives (ICs), respectively; five were on subdermal implant. Twenty-four non-users served as controls. Biodemographic and lipid profiles were determined. Total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), and very-low-density lipid lipoprotein cholesterol (VLDLC), were determined. Castelli index I and II were calculated. The mean age difference between the HC and control groups was insignificant. However, diastolic blood pressure (BP) differences were significant (P=0.006). The body mass index (BMI) of the OC and IC groups were significantly different from the control group (P=0.003 and P=0.008, respectively). TC levels for the control and case groups were 3.35±0.62 mmol/L and 4.07±0.91 mmol/L, respectively (P=0.002). LDLC levels for the control and case groups were 1.74±0.57 mmol/L and 2.38±0.84 mmol/L, respectively (P=0.003). Castelli index I (TC/HDLC) and II (LDLC/HDLC) were significantly different between the control and OC groups (P=0.026 and P=0.014, respectively). Spearman’s rho correlation showed significant influence of HC use on TG (P=0.026), TC (P=0.000), LDLC (P=0.004), and VLDLC (P=0.026) over time. HC use is associated with significant increases in BMI, diastolic BP, TC, LDLC, and Castelli index I and II. These changes carry a potential risk in the development of CV disease.