Circulating miRNAs as early indicators of diet and physical activity response in women with metastatic breast cancer.
Circulating miRNAs as early indicators of diet and physical activity response in women with metastatic breast cancer.
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DOI：
10.2144/fsoa-2020-0208
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发表时间：
2021-03-04
影响因子：
2.5
通讯作者：
Stolley M
中科院分区：
文献类型：
--
作者：
Olson J;Sheean P;Matthews L;Chitambar CR;Banerjee A;Visotcky A;Bonini M;Stolley M
转移性乳腺癌(MBC)的治疗提高了存活率，但往往会带来长期的症状负担。我们对MBC妇女循环血清中的84个miRNAs进行了分子表征，以探索干预反应的可能早期指标。MiR-10a-5p和miR-211-5p的表达水平在无反应者中下调，而在应答者中上调(miR-10a-5p：0.40倍和8倍；miR 211-5p：0.47倍和4倍)。MIR-205-5p在无应答者和应答者中都表达上调，但在应答者中上调程度更大(1.8倍和6倍)。此外，miR-10a-5p水平与IL-6表达水平呈负相关(r=0.412)。对这些途径的探索可能揭示旨在改善MBC妇女生活质量和影响疾病进展的生活方式干预的作用机制。随着转移性乳腺癌妇女的治疗提高存活率，需要减轻症状负担的干预措施。我们检测了转移性乳腺癌患者的血清，她们参与了改善饮食和增加体力活动的生活方式干预。发现了三个miRNAs，它们可以作为生活方式干预提高生活质量和影响疾病进展的能力的早期指标。三个miRNAs可以预测转移性乳腺癌患者对生活方式干预的反应。
Treatments for metastatic breast cancer (MBC) improve survival but often impose prolonged symptom burden. We performed molecular characterization of 84 miRNAs in the circulating serum of women with MBC to explore possible early indicators of intervention response. Expression levels of miR-10a-5p and miR-211-5p were downregulated in nonresponders, but upregulated in responders (miR-10a-5p: 0.40-fold and eightfold; miR 211-5p: 0.47-fold and fourfold). miR-205-5p expression was upregulated in both nonresponders and responders, but to a greater extent in responders (1.8-fold and sixfold). Additionally, levels of miR-10a-5p were negatively correlated with expression levels of IL-6 (r = -0.412). Exploration of these pathways may reveal mechanisms of action in lifestyle interventions aimed at improving quality of life and impacting disease progression for women with MBC. As treatment for women with metastatic breast cancer improves survival rates, interventions are needed that relieve symptom burden. We examined the serum of women with metastatic breast cancer who participated in a lifestyle intervention that improved diet and increased physical activity. Three miRNAs were discovered that may serve as early indicators of the ability of lifestyle interventions to improve quality of life and impact disease progression. Three miRNAs may predict how women with metastatic breast cancer respond to lifestyle interventions.