Fluoxetine but not risperidone increases sociability in the BTBR mouse model of autism
Fluoxetine but not risperidone increases sociability in the BTBR mouse model of autism
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DOI：
10.1016/j.pbb.2010.09.012
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发表时间：
2011-01-01
影响因子：
3.6
通讯作者：
Chadman, Kathryn K.
中科院分区：
文献类型：
--
作者：
Chadman, Kathryn K.
自闭症是一种神经发育障碍，其特征是社会交往异常，社交沟通受损，重复行为和/或兴趣受限，以及几种相关症状，包括易怒和焦虑。利培酮被批准用于自闭症患者的易怒和自我伤害行为。氟西汀正在接受与自闭症相关的重复行为和焦虑的评估。这两种药物在BTBR T+Tf/J(BTBR)小鼠自闭症模型和C57BL/6J(B6)小鼠身上进行了评估，通过三室社交接近测试和高架+迷宫来确定对社交和焦虑的影响。氟西汀增加了BTBR小鼠的社交能力，定义为与陌生人相处的时间，而不影响在高架加迷宫中的焦虑样行为。氟西汀没有显著改变B6小鼠的这两种行为。利培酮不影响社交或类似焦虑的行为，并且在较高剂量时具有类似镇静的作用。提示氟西汀对自闭症患者的社会行为有一定的治疗作用。(C)2010 Elsevier Inc.保留所有权利。
Autism, a neurodevelopmental disorder, is characterized by abnormal social interactions, impaired social communication and repetitive behaviors and/or restricted interests, along with several associated symptoms including irritability and anxiety. Risperidone is approved for the irritability and self-injurious behaviors found in autism. Fluoxetine is under evaluation for the repetitive behaviors and anxiety associated with autism. These two drugs were evaluated in the BTBR T + tf/J (BTBR) mouse model of autism and C57BL/6J (B6) mice by using the three-chambered social approach test and elevated plus maze to determine effects on sociability and anxiety. Fluoxetine increased sociability, defined as time spent with a stranger mouse, in the BTBR mice without affecting anxiety-like behavior in the elevated plus maze. Fluoxetine did not significantly change either behavior in the B6 mice. Risperidone did not affect sociability or anxiety-like behaviors and had a sedative-like effect at higher doses. These findings suggest that fluoxetine may have some therapeutic efficacy for treating the social behaviors in autism. (C) 2010 Elsevier Inc. All rights reserved.