TCDD (2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN) CAUSES REDUCTION IN THE LOW-DENSITY LIPOPROTEIN (LDL) RECEPTOR ACTIVITIES IN THE HEPATIC PLASMA-MEMBRANE OF THE GUINEA-PIG AND RAT
TCDD (2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN) CAUSES REDUCTION IN THE LOW-DENSITY LIPOPROTEIN (LDL) RECEPTOR ACTIVITIES IN THE HEPATIC PLASMA-MEMBRANE OF THE GUINEA-PIG AND RAT
复制标题
DOI：
10.1016/0006-291x(84)91337-8
复制
发表时间：
1984-01-01
影响因子：
3.1
通讯作者：
MADHUKAR, BV
中科院分区：
文献类型：
--
作者：
BOMBICK, DW;MATSUMURA, F;MADHUKAR, BV
对年轻的雄性豚鼠给予1 μ g/kg（单次腹腔注射，10天后研究）2，3，7，8-四氯二苯并-对-二恶英（TCDD），导致低密度脂蛋白（LDL）与其肝质膜上受体的结合显著减少。这种LDL结合的降低不是由给药动物的摄食量减少引起的，因为配对喂养的对照动物的LDL结合显著高于给药动物。与对照组相比，处理组动物的原代肝细胞内化LDL的能力降低。这种质膜功能的变化可以解释由此产生的高脂血症，特别是高胆固醇血症，这是由于TCDD管理。
Administration of 1 .mu.g/kg (single i.p. injection and studied after 10 days) of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to young male guinea pigs caused a significant reduction in binding of low-density lipoprotein (LDL) to its receptor on the hepatic plasma membrane. This reduction in LDL binding was not caused by the decrease of food intake by treated animals since pair-fed control animals had significantly higher LDL binding than treated animals. Primary hepatocytes from treated animals had a reduced ability to internalize LDL than controls. Such a change in the plasma membrane function may explain the resulting hyperlipidemia particularly hypercholesterolemia which occurred as a result of TCDD administration.