Strongly enhanced serum levels of vascular endothelial growth factor (VEGF) after polytrauma and burn
Strongly enhanced serum levels of vascular endothelial growth factor (VEGF) after polytrauma and burn
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DOI：
10.1515/cclm.1998.064
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发表时间：
1998-06-01
影响因子：
6.8
通讯作者：
Maly, FE
中科院分区：
文献类型：
--
作者：
Grad, S;Ertel, W;Maly, FE
血管生成是由组织损伤触发的修复机制的关键组成部分。血管内皮生长因子（VEGF）是血管生成的重要介质，因为它直接且特异性地作用于内皮细胞。在再生组织中局部产生的VEGF可能溢出到体循环中，并且测量循环VEGF的水平可以允许监测血管生成。为了确定严重创伤后循环VEGF是否增加，我们使用新建立的ELISA法检测了23例机械烧伤患者，55例多发性创伤患者和56例健康正常对照者的系列血清样本中VEGF的浓度。在烧伤患者中，血清VEGF在第1天（369.4 ± 88.0 pg/ml）和第3天（452.0 ± 65.3 pg/ml）升高，在第14天达到最高水平（1809.5 ± 239.7 pg/ml），在烧伤后第21天仍升高（11339.8 ± 208.7 pg/ml）（平均值± SEM，p
Angiogenesis is a key component of the repair mechanisms triggered by tissue injury. Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis, as it acts directly and specifically on endothelial cells. VEGF produced locally in regenerating tissue may spill over into the systemic circulation, and measuring levels of circulating VEGF may allow monitoring of angiogenesis. To determine whether circulating VEGF is increased after severe injury, we measured concentrations of VEGF in serial serum samples of 23 mechanical burn patients, 55 patients with multiple trauma and 56 healthy normal controls, using a newly established ELISA assay. In burn patients, serum VEGF was increased on day 1 (369.4 +/- 88.0 pg/ml) and on day 3 (452.0 +/- 65.3 pg/ml), reached highest levels on day 14(1809.5 +/- 239.7 pg/ml) and was still elevated on day 21 post-burn 11339.8 +/- 208.7 pg/ml) (mean +/- SEM, p