Characterization of Skin Microbiome in Tinea Pedis
Characterization of Skin Microbiome in Tinea Pedis
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足癣皮肤微生物组的特征
DOI：
10.1007/s12088-019-00816-y
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发表时间：
2019-12-01
影响因子：
3
通讯作者：
Yang, Lianjuan
中科院分区：
文献类型：
--
作者：
Liu, Xiaoping;Tan, Jingwen;Yang, Lianjuan
足癣与红色毛霉菌感染有关。然而，目前还不清楚是否有其他微生物参与了疾病的发病机制。对足癣患者和健康对照的微生物群落组成进行分析，以确定足癣的特征及其与临床类型的差异。我们发现足癣患者的微生物群落结构与健康对照组不同。此外，不同形态的足癣患者的皮肤微生物群也不同。健康对照组比足癣患者表现出更多的真菌多样性。足癣患者细菌和真菌以葡萄球菌和毛霉菌为主。与健康对照组比较，骨质疏松棒状杆菌减少，红色毛滴虫增多。在水泡性足癣中，结核杆菌的数量高于角化过度和指间型足癣。指间型足癣对细小棒状杆菌和红色毛滴虫的检出率较高。提示细菌可能参与了足癣的发病过程。
Tinea pedis has been associated with Trichophyton rubrum infection. However, it's not clear whether other microbes were implicated in disease pathogenesis. The composition of microbial communities of patients with tinea pedis and healthy controls were analyzed to identify the characteristics of tinea pedis and differences associated with clinical patterns. We found that microbial community structures were different in patients with tinea pedis compared with healthy controls. Moreover, skin microbiome varied in different forms of tinea pedis. Healthy controls exhibited greater fungal diversity than patients with tinea pedis. In patients with tinea pedis, the dominant bacterial and fungal genera were Staphylococcus and Trichophyton. Compared with healthy controls, Corynebacterium tuberculostearicum was decreased and T. rubrum was increased. C. tuberculostearicum was more abundant in vesicular tinea pedis than in hyperkeratotic and interdigital tinea pedis. Interdigital tinea pedis had a higher detection rate of Corynebacterium minutissimum and T. rubrum than the other forms. These results indicated that bacterial microbes may take part in the development of tinea pedis.