Episodic-like memory in mice: Simultaneous assessment of object, place and temporal order memory
Episodic-like memory in mice: Simultaneous assessment of object, place and temporal order memory
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DOI：
10.1016/j.brainresprot.2005.08.001
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发表时间：
2005-12-01
期刊：
影响因子：
--
通讯作者：
Silva, MAS
中科院分区：
文献类型：
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作者：
Dere, E;Huston, JP;Silva, MAS
情景记忆是指对过去独特经历的有意识回忆，包括发生的“什么”以及发生的“地点”和“时间”。由于在许多神经精神疾病中都发现了情景记忆缺陷，例如阿尔茨海默氏病，因此有几种药理学、病变和遗传动物模型可供使用，因此需要类似情景记忆的动物模型，可用于设计适当的治疗方法。然而，即使排除了动物的有意识回忆问题，情景记忆也很难在非人类哺乳动物中得到证明，因为它还不可能证明对“什么”、“哪里”和“何时”的综合记忆。我们设计了一个三试验“什么”、“哪里”和“何时”的物体探索任务，其中结合了不同版本的新奇偏好范式，以包含（a）物体识别记忆，（b）物体所在位置的记忆探索了（c）在不同时间点呈现的对象的时间顺序记忆。我们的结果表明，小鼠能够（a）识别以前探索过的物体，（b）记住以前遇到特定物体的位置，以及（c）区分不同物体出现的相对新近度。我们建议，我们的协议提供对小鼠“什么”、“哪里”和“何时”的对象记忆的同时评估，可能有助于寻找情景记忆的神经基质、筛选促眠药物以及影响情景记忆的神经精神疾病遗传模型的行为表型。 (c) 2005 Elsevier B.V. 保留所有权利。
Episodic memory refers to the conscious recollection of a unique past experience in terms of "what" happened and "where" and "when" it happened. Since deficits in episodic memory are found in a number of neuropsychiatric diseases, such as Alzheimer's disease, for which several pharmacological, lesion and genetic animal models are available, there is a need for animal models of episodic-like memory, which can be used to devise appropriate treatments. However, even when the problem of conscious recollection in animals is factored out, episodic memory has been difficult to demonstrate in nonhuman mammals because it has not yet been possible to demonstrate an integrated memory for "what",- "where" -and- "when".We designed a three-trial "what",- "where" -and- "when" object exploration task in which different versions of the novelty preference paradigm were combined to subsume (a) object recognition memory, (b) the memory for locations in which objects were explored and (c) the temporal order memory for objects presented at distinct time points. Our results suggest that mice are able to (a) recognize previously explored objects, (b) remember the location in which particular objects were previously encountered and (c) discriminate the relative recency in which different objects were presented. We suggest that our protocol providing the simultaneous assessment of object memory for "what",- "where" -and- "when" in mice might be useful in the search for the neural substrates of episodic memory, the screening for promnestic drugs and the behavioral phenotyping of genetic models of neuropsychiatric diseases affecting episodic memory. (c) 2005 Elsevier B.V. All rights reserved.