Temporal coupling of rapid eye movements and cerebral activities during REM sleep
Temporal coupling of rapid eye movements and cerebral activities during REM sleep
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DOI：
10.1016/j.clinph.2008.10.006
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发表时间：
2009-01-01
影响因子：
4.7
通讯作者：
Hori, Tadao
中科院分区：
文献类型：
--
作者：
Ogawa, Keiko;Abe, Takashi;Hori, Tadao
目的：我们调查事件相关电位的时间锁定的快速眼动（REM）sleep.Method的开始和结束的快速眼动（REM）：9名健康的大学生参加了这项研究。数据是在睡眠实验室中收集的。快速眼动睡眠期间的快速眼动记录在自然夜间睡眠。在视觉触发任务期间记录清醒期间的扫视。对事件相关电位进行平均，时间锁定到眼球运动的开始和偏移。结果：在REM睡眠期间，枕区发生类似λ的反应，时间锁定到快速眼球运动的偏移（类似于清醒期间发生的情况）。此外，我们还发现，在REM睡眠期间，在大约200 ms时出现一个正电位（P200 r），其最大振幅出现在中央区，并且时间锁定在快速眼动的开始;而在清醒时则没有观察到这种电位。在REM睡眠期间，P200 r随着快速眼球运动的开始而发生，意义：我们证明了快速眼动和大脑活动在REM睡眠期间的时间耦合。这些活动可能为将来研究REM睡眠期间的大脑功能提供有用的基础。(C)2008年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objectives: We investigated event-related potentials time locked to the onset and offset of rapid eye movements during rapid eye movement (REM) sleep.Method: Nine healthy university students participated in this study. Data were collected in a sleep laboratory. Rapid eye movements during REM sleep were recorded during natural nocturnal sleep. Saccades during wakefulness were recorded during a visually triggered task. Event-related potentials were averaged, time-locked to the onset and offset of eye movements.Results: During REM sleep, a lambda-like response occurred over the occipital region, time-locked to the offset of rapid eye movements (similar to what occurs during wakefulness). Moreover, we found that a positive potential (P200r) occurred at about 200 ms, with the maximal amplitude over the central region and time-locked to the onset of rapid eye movements during REM sleep; this potential was not observed during wakefulness.Conclusions: During REM sleep, the P200r occurs with the start of rapid eye movements, and then the lambda-like response occurs after termination of the movements.Significance: We demonstrated temporal coupling of rapid eye movements and cerebral activities during REM sleep. These activities might provide a useful basis for future investigations of brain functions during REM sleep. (C) 2008 international Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.