LONG-TERM EFFICACY OF ORAL CISAPRIDE IN SYMPTOMATIC UPPER GUT DYSMOTILITY
LONG-TERM EFFICACY OF ORAL CISAPRIDE IN SYMPTOMATIC UPPER GUT DYSMOTILITY
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DOI：
10.1007/bf01297028
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发表时间：
1991-05-01
影响因子：
3.1
通讯作者：
MALAGELADA, JR
中科院分区：
文献类型：
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作者：
ABELL, TL;CAMILLERI, M;MALAGELADA, JR
我们在21例临床和测压诊断为胃轻瘫（N = 9; 7例因糖尿病）或慢性假性肠梗阻（N = 12）的胃郁积患者中进行了为期12个月的西沙必利（10 mg，每日3次）试验。在基线和12个月结束时进行放射性核素固液胃排空试验。每月通过日记和每三个月由研究者评估症状;以标准化方式对症状的频率和严重程度进行评分。21例患者服用西沙必利1年后，固体和液体胃排空均明显改善（P < 0.05）。在慢性假性肠梗阻患者中，主要是固体胃排空的改善;相反，胃轻瘫患者的液体排空改善更大。胃轻瘫组的总症状评分显著改善（中位评分：基线时8分比1年时6分，P < 0.05），但慢性假性肠梗阻患者的总症状评分无显著改善（基线时中位评分10分比1年时9分）。同样，胃轻瘫组的体重也有改善的趋势。未观察到明显的副作用。我们得出的结论是，在为期12个月的开放试验中，西沙比利可有效改善胃停滞患者的胃排空，并持续改善胃轻瘫患者的症状。
We conducted a 12-month trial of cisapride (10 mg three times a day) in 21 patients with gastric stasis due to clinically and manometrically diagnosed gastroparesis (N = 9; seven due to diabetes) or chronic intestinal pseudo-obstruction (N = 12). Radionuclide solid-liquid gastric emptying tests were performed at baseline and at the end of the 12-month period. Symptoms were assessed monthly by diary and every three months by the investigators; frequency and severity of symptoms were scored in a standardized manner. For the whole group of 21 patients, gastric emptying of both solids and liquids improved significantly after one year of cisapride (P < 0.05). Among chronic intestinal pseudoobstruction patients, there was predominantly an improvement in gastric emptying of solids; in contrast, patients with gastroparesis had a greater improvement in liquid emptying. Total symptom score improved significantly in the gastroparesis group (median score: 8 at baseline vs 6 at one year, P < 0.05) but not in the chronic intestinal pseudoobstruction patients (median score at baseline 10 vs 9 at one year). Similarly, body weight showed a trend towards improvement in the gastroparesis group. No significant side effects were noted. We conclude that during a 12-month open trial, cisapride was effective in improving gastric emptying in patients with gastric stasis and consistently improved symptoms in those with gastroparesis.