Norethindrone acetate enhances the antiatherogenic effect of 17beta-estradiol: a secondary prevention study of aortic atherosclerosis in ovariectomized cholesterol-fed rabbits.
Norethindrone acetate enhances the antiatherogenic effect of 17beta-estradiol: a secondary prevention study of aortic atherosclerosis in ovariectomized cholesterol-fed rabbits.
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醋酸炔诺酮增强 17β-雌二醇的抗动脉粥样硬化作用：一项对卵巢切除胆固醇喂养的兔子主动脉粥样硬化的二级预防研究。
DOI：
10.1161/01.atv.18.6.902
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
C. Christiansen
中科院分区：
文献类型：
--
作者：
P. Alexandersen;J. Haarbo;I. Sandholdt;M. Shalmi;H. Lawaetz;C. Christiansen
The influence of progestogens in combination with 17beta-estradiol (E2) on cardiovascular disease remains controversial. This study investigated the effect of norethindrone acetate (NETA) combined with E2 on aortic atherosclerosis. Eighty mature female rabbits were ovariectomized, then fed a cholesterol-rich diet (240 mg/d) for 14 weeks to induce aortic atherosclerosis. They were randomized to four equally large groups for the following 38-week intervention period. One group received placebo, another group oral E2 4 mg daily (E2), and the last two groups oral E2 4 mg daily combined with either NETA 1 mg (E2NETA1) or NETA 3 mg (E2NETA3). The cholesterol intake was reduced to a "maintenance" level of 80 mg/d during the intervention period. Total serum cholesterol and ultracentrifuged lipoproteins were analyzed enzymatically throughout the study. The cholesterol content in the aortic wall was 2.76+/-0.44 micromol/cm2 (mean+/-SEM) in the E2NETA1 group, 1.77+/-0.37 micromol/cm2 in the E2NETA3 group, 5.46+/-0.77 micromol/cm2 in the E2 group, and 7.20+/-0.94 micromol/cm2 in the placebo group (ANOVA P<0.0001). The difference (in the aortic cholesterol accumulation) between the E2 and each of the combined E2/NETA groups was statistically significant (P<0.01) but could only partly be explained by the differences in serum lipids and lipoproteins. In conclusion, NETA enhances the antiatherogenic effect of E2 in cholesterol-fed rabbits. This effect is only partially mediated through changes in serum lipids and lipoproteins.
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DOI：
10.1161/01.atv.10.6.1051
发表时间：
1990-11-01
期刊：
ARTERIOSCLEROSIS
影响因子：
--
作者：
ADAMS, MR;KAPLAN, JR;CLARKSON, TB
通讯作者：
CLARKSON, TB
影响因子：
8.7
作者：
Adams, MR;Register, TC;Williams, JK
通讯作者：
Williams, JK
影响因子：
158.5
作者：
Grodstein, F;Stampfer, MJ;Hennekens, CH
通讯作者：
Hennekens, CH
影响因子：
158.5
作者：
COLDITZ, GA;WILLETT, WC;HENNEKENS, CH
通讯作者：
HENNEKENS, CH
雌激素和黄体酮替代疗法可减少绝经后食蟹猴冠状动脉中低密度脂蛋白的积累。
DOI：
10.1172/jci115526
发表时间：
1991
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Wagner,JD;Clarkson,TB;StClair,RW;Schwenke,DC;Shively,CA;Adams,MR
通讯作者：
Adams,MR