BRIGHT LIGHT RESETS THE HUMAN CIRCADIAN PACEMAKER INDEPENDENT OF THE TIMING OF THE SLEEP-WAKE CYCLE
BRIGHT LIGHT RESETS THE HUMAN CIRCADIAN PACEMAKER INDEPENDENT OF THE TIMING OF THE SLEEP-WAKE CYCLE
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DOI：
10.1126/science.3726555
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发表时间：
1986-08-08
期刊：
影响因子：
56.9
通讯作者：
KRONAUER, RE
中科院分区：
文献类型：
--
作者：
CZEISLER, CA;ALLAN, JS;KRONAUER, RE
人类的昼夜节律曾经被认为对光不敏感，通过社会接触或睡眠-觉醒时间表来实现与24小时的同步。然而，对强光的强度依赖性神经内分泌反应的证明导致人们重新考虑光作为人类昼夜节律起搏器的可能同步器。在一项实验室研究中，一名老年妇女的昼夜节律起搏器的输出在连续七个晚上暴露于4小时的强光之前和之后进行了监测，在普通室内照明的对照研究之前和之后进行了监测，而她的睡眠-觉醒时间表和社会接触保持不变。晚上暴露在明亮的灯光下会导致她的昼夜节律起搏器延迟6小时，这一点可以通过体温和皮质醇分泌的记录来证明。这种转变的出乎意料的幅度、速度和稳定性挑战了人类昼夜节律相位重置能力的现有概念，并表明暴露于强光确实可以重置人类昼夜节律起搏器，该起搏器控制生理、行为和认知功能的日常变化。
Human circadian rhythms were once thought to be insensitive to light, with synchronization to the 24-hour day accomplished either through social contacts or the sleep-wake schedule. Yet the demonstration of an intensity-dependent neuroendocrine response to bright light has led to renewed consideration of light as a possible synchronizer of the human circadian pacemaker. In a laboratory study, the output of the circadian pacemaker of an elderly woman was monitored before and after exposure to 4 hours of bright light for seven consecutive evenings, and before and after a control study in ordinary room light while her sleep-wake schedule and social contacts remained unchanged. The exposure to bright light in the evening induced a 6-hour delay shift of her circadian pacemaker, as indicated by recordings of body temperature and cortisol secretion. The unexpected magnitude, rapidity, and stability of the shift challenge existing concepts regarding circadian phase-resetting capacity in man and suggest that exposure to bright light can indeed reset the human circadian pacemaker, which controls daily variations in physiologic, behavioral, and cognitive function.