ARED 3.0: the large and diverse AU-rich transcriptome.
ARED 3.0: the large and diverse AU-rich transcriptome.
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DOI：
10.1093/nar/gkj052
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发表时间：
2006-01-01
影响因子：
14.9
通讯作者：
Khabar KS
中科院分区：
文献类型：
--
作者：
Bakheet T;Williams BR;Khabar KS
一项综合搜索利用了来自人类基因组数据库的大量mRNA数据，此外，表达序列标签（EST）数据库对富含AU元件（AREs）的mRNA数据库（ARED）的这一最新更新进行了特征描述。大量的ARE - mRNA，多达4000个，被恢复出来，其中包括许多ARE的替代形式。这个数字根据基因总数的不同，占人类基因的5 - 8%。新的ARED不仅包含更多样化的ARE - mRNAs，而且数据库网站还提供了额外的功能和增强的搜索能力。这些包括AREs的类别和聚类、来源mRNAs、EST证据、构建信息、基因列表的检索，以及与当前和新的美国国家生物技术信息中心（NCBI）数据（如Entrez ID和Unigene）的整合。基因本体分析表明，与整个基因组相比，ARED在功能多样性上存在显著差异。许多ARE基因介导调节过程、对外部刺激的反应、RNA代谢以及发育过程，特别是早期和瞬时反应的过程。对mRNA周转的广泛关注以及AREs在健康和疾病中的重要性，凸显了ARE基因的汇编的重要性。
A comprehensive search that utilized a large set of mRNA data from human genome databases and additionally, expressed sequence tag (EST) database characterized this latest update of AU-rich elements (AREs) containing mRNA database (ARED). A large number of ARE-mRNA, as much as 4000, were recovered and include many of ARE alternative forms. This number represents as much as 5–8% of the human genes depending on the entire number of genes. The new ARED does not contain only larger and diverse number of ARE-mRNAs but additional functionality and enhanced search capabilities are given in the database website . These include class and cluster of AREs, source mRNAs, EST evidence, buildup information, retrieval of lists of genes, and integration with current and new NCBI data, such as Entrez ID and Unigene. Gene Ontology analysis shows there are significant differences in functional diversity of ARED when compared with the overall genome. Many of ARE-genes mediate regulatory processes, reactions to outside stimuli, RNA metabolism, and developmental processes particularly those of early and transient responses. The wide interest in mRNA turnover and importance of AREs in health and disease signify the compilation of ARE-genes.