Role of Contrast-Enhanced Ultrasound Sonography in the Medical Diagnostics of the Disease Activity in Patients With Takayasu Arteritis
Role of Contrast-Enhanced Ultrasound Sonography in the Medical Diagnostics of the Disease Activity in Patients With Takayasu Arteritis
复制标题
超声造影在大动脉炎患者疾病活动性医学诊断中的作用
DOI：
10.1109/access.2019.2896386
复制
发表时间：
2019-01-01
期刊：
影响因子：
3.9
通讯作者：
Tian, Jiawei
中科院分区：
文献类型：
--
作者：
Zhao, Chen;Yu, Dandan;Tian, Jiawei
准确诊断多发性大动脉炎（TA）和评估其活动性可能带来重大挑战。在本文中，我们试图调查临床活动和增强超声造影（CEUS）获得的血管壁与TA患者之间的相关性，并评估CEUS是否可以用来评估TA的疾病活动。入选20例颈动脉受累的TA患者，根据NIH评分方法分为活动组和非活动组。采集白色血细胞计数、C反应蛋白（CRP）和红细胞沉降率（ESR）。进行常规超声以获取动脉外径（D）、动脉壁内膜-中层厚度（IMT）、面积狭窄百分比、收缩期峰值流速、舒张末期流速和阻力指数。CEUS测量增强强度（EI）、峰值强度（DPI）和达峰时间。分析显示，与非活动组相比，活动组的D和IMT显著更高（6.50 +/- 1.80 vs 9.20 +/- 4.00 mm，1.80 +/- 0.40 vs 2.40 +/- 0.70 mm，p < 0.05）。活性组的EI和DPI也显著更高（38.20 +/- 10.62 vs 80.80 +/- 23.60 IU，46.20 +/- 10.20 vs 90.30 +/- 24.60 IU，p < 0.05）。EI、DPI与CRP、ESR具有良好的相关性。因此，我们的研究表明，CEUS可以提高传统超声在区分活动和非活动TA方面的有效性。
The accurate diagnosis of Takayasu arteritis (TA) and the evaluation of its activity can bring significant challenges. In this paper, we sought to investigate a correlation between clinical activity and the enhancement of vessel wall acquired by contrast-enhanced ultrasound sonography (CEUS) in patients with TA, and to evaluate whether CEUS can be used to assess the disease activity of TA. Twenty TA patients with their carotid arteries affected were enrolled and divided into the active group and the inactive group according to the NIH scoring method. The white blood cell counts, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were obtained. Conventional ultrasound was performed to acquire the external diameter of the artery (D), intima-media thickness of the arterial wall (IMT), percent area stenosis, peak systolic velocity, end diastolic velocity, and resistance index. CEUS was performed to acquire the enhanced intensity (EI), derived peak intensity (DPI), and time to peak. The analysis showed that compared with the inactive group, D and IMT were significantly higher in the active group (6.50 +/- 1.80 versus 9.20 +/- 4.00 mm, 1.80 +/- 0.40 versus 2.40 +/- 0.70 mm, p < 0.05). EI and DPI were also significantly higher in the active group (38.20 +/- 10.62 versus 80.80 +/- 23.60 IU, 46.20 +/- 10.20 versus 90.30 +/- 24.60 IU, p < 0.05). Meanwhile, EI and DPI showed good correlation with CRP and ESR. Therefore, our study demonstrated that CEUS can increase the effectiveness of conventional ultrasound in differentiating active and inactive TA.