Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors.
Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors.
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DOI：
10.1016/j.mam.2012.07.006
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发表时间：
2013-04
影响因子：
10.6
通讯作者：
Goldman, I. David
中科院分区：
文献类型：
--
作者：
Zhao, Rongbao;Goldman, I. David
关键词：
还原叶酸载体（RFC，SLC19A1），硫胺素转运蛋白-1（ThTr1，SLC19A2）和硫胺素转运蛋白-2（ThTr2，SLC19A3）来自同一家族的溶质载体。SLC19A1转运叶酸，但不转运硫胺素。SLC19A2和SLC19A3转运硫胺素，但不转运叶酸。SLC19A1和SLC19A2将其底物递送至全身组织; SLC19A3介导肠道硫胺素吸收。质子偶联叶酸转运蛋白（PCFT，SLC46A1）是叶酸通过近端小肠的顶端刷状缘膜吸收的机制。两种叶酸受体（FOLR1和FOLR2）通过内吞过程介导叶酸跨上皮转运。叶酸转运蛋白是用于治疗癌症和炎性疾病的药物递送途径。常染色体隐性遗传疾病与SLC46A1（遗传性叶酸吸收不良）、FOLR1（脑叶酸缺乏）、SLC19A2（硫胺素反应性巨幼细胞性贫血）和SLC19A3（生物素反应性基底神经节疾病）编码基因突变相关。
The reduced folate carrier (RFC,SLC19A1), thiamine transporter-1 (ThTr1,SLC19A2) and thiamine transporter-2 (ThTr2,SLC19A3) evolved from the same family of solute carriers. SLC19A1 transports folates but not thiamine. SLC19A2 and SLC19A3 transport thiamine but not folates. SLC19A1 and SLC19A2 deliver their substrates to systemic tissues; SLC19A3 mediates intestinal thiamine absorption. The proton-coupled folate transporter (PCFT,SLC46A1) is the mechanism by which folates are absorbed across the apical-brush-border membrane of the proximal small intestine. Two folate receptors (FOLR1 and FOLR2) mediate folate transport across epithelia by an endocytic process. Folate transporters are routes of delivery of drugs for the treatment of cancer and inflammatory diseases. There are autosomal recessive disorders associated with mutations in genes encoded for SLC46A1 (hereditary folate malabsorption), FOLR1 (cerebral folate deficiency), SLC19A2 (thiamine-responsive megaloblastic anemia), and SLC19A3 (biotin-responsive basal ganglia disease).
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