Extragastric Diseases and Helicobacter pylori
Extragastric Diseases and Helicobacter pylori
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DOI：
10.1111/hel.12256
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发表时间：
2015-09-01
期刊：
影响因子：
4.4
通讯作者：
Kountouras, Jannis
中科院分区：
文献类型：
--
作者：
Franceschi, Francesco;Gasbarrini, Antonio;Kountouras, Jannis
幽门螺杆菌感染的胃外表现在整个H. pylori世界的确H幽门可以干扰胃内外的许多生物过程，可能影响或决定胃外许多疾病的发生。虽然它在特发性血小板减少性紫癜和缺铁性贫血中的作用已经被认识，但新的证据表明H。幽门螺杆菌可能增加急性冠状动脉综合征的风险，导致胰岛素抵抗，并与神经变性、呼吸系统和其他先前与其他疾病相关的各种疾病有关。不同的致病机制已被假设，包括诱导低度炎症状态和分子模拟机制的发生。这篇综述总结了去年发表的关于这一主题的最相关的研究结果。
The extragastric manifestations of Helicobacter pylori infection still remain a very strong topic throughout the H. pylori world. Indeed, H. pylori may interfere with many biological processes, both inside and outside of the stomach, possibly influencing or determining the occurrence of many diseases outside of the stomach. While its role in idiopathic thrombocytopenic purpura and sideropenic anemia has already been recognized, emerging evidence suggests that H. pylori may increase the risk of acute coronary syndrome, contribute to insulin resistance and be associated with neurodegenerative, respiratory, and other miscellaneous disorders previously associated with other conditions. Different pathogenic mechanisms have been hypothesized, including the induction of a low-grade inflammatory state and the occurrence of molecular mimicry mechanisms. This review summarizes the results of the most relevant studies published on this topic in the last year.