Accelerated forgetting of real-life events in Transient Epileptic Amnesia
Accelerated forgetting of real-life events in Transient Epileptic Amnesia
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DOI：
10.1016/j.neuropsychologia.2010.07.001
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发表时间：
2010-09-01
期刊：
影响因子：
2.6
通讯作者：
Zeman, A. Z.
中科院分区：
文献类型：
--
作者：
Muhlert, N.;Milton, F.;Zeman, A. Z.
短暂性癫痫发作（TEA）是颞叶癫痫的一种形式，与发作和发作间期记忆障碍有关。一些TEA患者表现出加速的长期遗忘（CALF），其中语言和非语言材料的记忆通常在短时间内保留，但在几天到几周内以异常快的速度消退。这项研究解决了三个问题，关于ALF在TEA：（一）是否现实生活中的事件经历ALF在类似的方式，以实验室为基础的刺激;（二）是否ALF可以在24小时内检测到;（三）是否程序性记忆容易受到ALF。11名TEA患者和11名匹配的健康对照者佩戴了一种新型的自动相机。SenseCam，同时参观当地的景点。在同一天以及延迟一天、一周和三周后评估事件图像的记忆。对现实生活事件的遗忘与对单词列表的遗忘以及程序性记忆任务的表现进行了比较。在他们的旅行当天，患者和对照组回忆起相似数量的主要事件，相关的次要细节（连续事件，思想和感官信息）和单词列表中的项目。相比之下，患者在三周内的主要事件中显示ALF，在第一天的连续事件，想法和话语中显示ALF。程序性记忆任务的保留在三周内是正常的。结果表明，TEA中的加速遗忘：（i）影响对现实生活事件以及实验室刺激的记忆;（ii）在第一天最大;（iii）特定于陈述性记忆。(C)2010爱思唯尔有限公司版权所有。
Transient Epileptic Amnesia (TEA) is a form of temporal lobe epilepsy associated with ictal and interictal memory disturbance. Some patients with TEA exhibit Accelerated Long-term Forgetting CALF), in which memory for verbal and non-verbal material is retained normally over short delays but fades at an unusually rapid rate over days to weeks. This study addresses three questions about ALF in TEA: (i) whether real-life events undergo ALF in a similar fashion to laboratory-based stimuli; (ii) whether ALF can be detected within 24h; (iii) whether procedural memories are susceptible to ALF. Eleven patients with TEA and eleven matched healthy controls wore a novel, automatic camera. SenseCam, while visiting a local attraction. Memory for images of events was assessed on the same day and after delays of one day, one week, and three weeks. Forgetting of real-life events was compared with forgetting of a word list and with performance on a procedural memory task. On the day of their excursion, patients and controls recalled similar numbers of primary events, associated secondary details (contiguous events, thoughts and sensory information) and items from the word list. In contrast, patients showed ALF for primary events over three weeks, with ALF for contiguous events, thoughts and words over the first day. Retention on the procedural memory task was normal over three weeks. The results indicate that accelerated forgetting in TEA: (i) affects memory for real-life events as well as laboratory stimuli; (ii) is maximal over the first day; and (iii) is specific to declarative memories. (C) 2010 Elsevier Ltd. All rights reserved.