ROLE OF CALCIUM IN GLUCAGON-RELEASE - INTERACTIONS BETWEEN ARGININE AND CALCIUM
ROLE OF CALCIUM IN GLUCAGON-RELEASE - INTERACTIONS BETWEEN ARGININE AND CALCIUM
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DOI：
10.1159/000178749
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发表时间：
1976-01-01
期刊：
影响因子：
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通讯作者：
MALAISSE, WJ
中科院分区：
文献类型：
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作者：
LECLERCQMEYER, V;MARCHAND, J;MALAISSE, WJ
用离体灌流的大鼠胰腺研究了精氨酸和钙在胰高血糖素释放中的相互关系。在正常的2 mM Ca浓度的存在下，10 mM精氨酸引起双相胰高血糖素释放，这种反应的幅度与灌注液的葡萄糖浓度呈负相关。在最低3.3 mM葡萄糖浓度下，经过长时间（40分钟）和短时间（10分钟）的Ca剥夺后，精氨酸诱导的胰高血糖素释放受到抑制。Ca对于精氨酸作为α-精氨酸受体的刺激物的识别或有效性是必需的。cell.钙可能发挥多种作用。sbd.允许，抑制和stimulatory.sbd.in胰高血糖素分泌。Ca通过其在α-SMA中发挥这样的多功能作用的密切机制。细胞仍有待阐明。
The interrelationship between arginine and Ca in glucagon release was studied using the in vitro perfused rat pancreas. In the presence of a normal 2 mM Ca concentration, 10 mM arginine provoked biphasic glucagon release, the amplitude of such a response being inversely related to the glucose concentration of the perfusate. At the lowest 3.3 mM glucose concentration, and after prolonged (40 min) and short (10 min) periods of Ca deprivation, arginine-induced glucagon release was inhibited. Ca is necessary for either the recognition or effectiveness of arginine as a stimulus to the .alpha.-cell. Ca may play a versatile role.sbd.permissive, inhibitory and stimulatory.sbd.in glucagon secretion. The intimate mechanisms by which Ca exerts such versatile actions in the .alpha.-cell remain to be elucidated.