FRACTIONATED ELECTROGRAMS FROM A COMPUTER-MODEL OF HETEROGENEOUSLY UNCOUPLED ANISOTROPIC VENTRICULAR MYOCARDIUM
FRACTIONATED ELECTROGRAMS FROM A COMPUTER-MODEL OF HETEROGENEOUSLY UNCOUPLED ANISOTROPIC VENTRICULAR MYOCARDIUM
复制标题
DOI：
10.1161/01.cir.92.6.1619
复制
发表时间：
1995-09-15
期刊：
影响因子：
37.8
通讯作者：
LESH, MD
中科院分区：
文献类型：
--
作者：
ELLIS, WS;AUSLANDER, DM;LESH, MD
不均匀偶联心肌和碎裂电图之间的关系尚未完全了解。本研究的目的是使用一个详细的非均匀各向异性心肌的计算机模型来测试的假设，同时从多个站点记录的电描记图的形态的空间变化增加的异质性intercellularcoupled.Methods和结果一张与Beeler-Schmidter离子动力学的元素与细胞质电阻率模型细胞。缝隙连接电阻值通过递归随机化分配，以产生异质耦合的分形图案，模拟梗死造成的损伤。模式的关联维数D测量细胞间偶联的异质性。计算未滤波单极电描记图的峰间振幅、持续时间、最小导数（最陡下坡）、拐点数、峰值功率频率和带宽。线性回归分析显示（P
Background The relation between heterogeneously coupled myocardium and fractionated electrograms is incompletely understood. The purpose of this study was to use a detailed computer model of nonuniformly anisotropic myocardium to test the hypothesis that spatial variation of morphology of electrograms recorded simultaneously from multiple sites increases with increasing heterogeneity of intercellular coupling.Methods and Results A sheet of elements with Beeler-Reuter ionic kinetics was coupled with cytoplasmic resistivity to model cells. Gap junctional resistance values were assigned by recursive randomization to produce a fractal pattern of heterogeneous coupling, simulating damage resulting from infarction. The correlation dimension of the pattern, D, measured heterogeneity of intercellular coupling. The peak-to-peak amplitude, duration, minimum derivative (steepest downslope), number of inflections, frequency of peak power, and bandwidth of unfiltered unipolar electrograms were calculated. Linear regressions indicate (P