Chemical Approaches to Prepare Modified Heparin and Heparosan Polymers for Biological Studies.
Chemical Approaches to Prepare Modified Heparin and Heparosan Polymers for Biological Studies.
复制标题
制备用于生物学研究的修饰肝素和 Heparosan 聚合物的化学方法。
DOI：
10.1007/978-1-0716-1398-6_23
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Arungundram,Sailaja
中科院分区：
文献类型：
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作者：
Raman,Karthik;Arungundram,Sailaja
Heparin is a potent clinically used anticoagulant. It is a heterogeneous mixture of polymers that contain a variety of sulfation patterns. Heparin polymers carrying rare 3-O-sulfated glucosamine units have been proven to be critical for binding to antithrombin and elicit an anticoagulant response. Heparins with other sulfation patterns are able to bind to a variety of other proteins such as FGF, VEGF, and CXCL-3. By modulating heparin’s sulfation pattern, it is possible to generate polymers that can regulate biological processes beyond hemostasis. In this chapter, we describe a variety of chemical modification methods, includingN-acetylation,N-deacetylation,N-sulfation,O-sulfation, selective 2-Odesulfation, and complete desulfation, to prepare heparin-like polymers with distinct sulfation patterns for conducting biological studies.
