Transition of the rabbit corpus luteum to estrogen dependence during early luteal development.
Transition of the rabbit corpus luteum to estrogen dependence during early luteal development.
复制标题
黄体发育早期兔子黄体向雌激素依赖的转变。
作者：
J. Miller;P. Keyes
兔黄体的早期发育在孕后6天从雌激素非依赖期转变为雌激素依赖期。在这份报告中，这种过渡到雌激素依赖的性质进行了探讨。在家兔交配后6.5-8.0 h（第0天），将排卵前卵泡自体移植到肾脏，建立异位黄体。此时，对家兔进行双侧卵巢切除。为了确定雌二醇是否可能由发育中的黄体或卵巢外来源瞬时产生，测量了外周血和肾血中的雌二醇浓度。外周血中雌二醇的浓度在发育的第4天没有显著变化，并且每天平均低于1.2 pg/ml。外周血、异位黄体肾引流血或对侧肾血液中雌二醇浓度无显著差异。因此，早期的发展…
The early development of the rabbit corpus luteum shifts by day 6 postcoitum from a period of estrogen independence to one of estrogen dependence. In this report, the nature of this transition to estrogen dependence has been explored. Ectopic corpora lutea were established in rabbits by autotransplanting preovulatory follicles to the kidney 6.5-8.0 h after mating (day 0). At this time, the rabbits were bilaterally ovariectomized. To determine whether estradiol might be produced transiently by the developing corpora lutea or by an extraovarian source, estradiol concentrations were measured in peripheral blood and in renal blood. The concentration of estradiol in peripheral blood did not vary significantly through day 4 of development, and, on each day, averaged less than 1.2 pg/ml. No significant differences were observed between the concentrations of estradiol in peripheral blood, in blood draining the kidney bearing ectopic corpora lutea, or in blood from the contralateral kidney. Thus, the early develop...