Influence of the oral cavity on insulin release in the rat.
Influence of the oral cavity on insulin release in the rat.
复制标题
口腔对大鼠胰岛素释放的影响。
DOI：
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复制
发表时间：
1976
影响因子：
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通讯作者：
A. Steffens
中科院分区：
文献类型：
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作者：
A. Steffens
测量未受干扰和自由活动大鼠的血糖和胰岛素水平。胰岛素水平在开始进食后的第1分钟开始升高；如果进食富含液体碳水化合物的食物，血糖水平只有在第3分钟才开始上升。胰岛素的释放遵循双相模式。如果在动物完成口服所需的同一时间将相同数量的食物注入胃内，则可以看到胰岛素释放延迟，胰岛素第二阶段释放被夸大。血糖水平在第3分钟开始上升，比口服时增加得更多。关于胰岛素的释放，如果使用无碳水化合物的流质食物而不是富含碳水化合物的流质食物，也可以观察到同样的现象。有人认为，口腔在胰岛素释放的第一阶段起主要作用，而胰岛素释放的第一阶段似乎对血糖和胰岛素水平的动态平衡很重要。
Blood glucose and insulin levels were measured in undisturbed and free-moving rats. The insulin level rose in the 1st min after the start of food intake; the glucose level began to increase only in the 3rd min if a fluid carbohydrate-rich food was eaten. The insulin release followed a biphasic pattern. If the same quantity of food ingested orally was injected into the stomach in the same time as the animals needed to complete oral ingestion, delayed insulin release could be seen and the second phase of insulin release was exaggerated. The glucose level, which started to rise in the 3rd min, increased much more than during oral ingestion. With respect to insulin release the same phenomena could be observed if carbohydrate-free fluid food was used instead of carbohydrate-rich fluid food. It is argued that the oral cavity plays a major role in the first phase of insulin release, which in its turn seems to be important in the homeostasis of the blood glucose and insulin levels.