Rapid early onset lymphocyte cell death in mice resistant, but not susceptible to Leishmania major infection.
Rapid early onset lymphocyte cell death in mice resistant, but not susceptible to Leishmania major infection.
复制标题
早发性淋巴细胞快速死亡的小鼠具有抵抗力，但不易受重大利什曼原虫感染。
DOI：
10.1023/a:1009601200580
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Newell,MK
中科院分区：
文献类型：
--
作者：
Desbarats,J;Stone,JE;Lin,L;Zakeri,ZF;Davis,GS;Pfeiffer,LM;Titus,RG;Newell,MK
Leishmania major (Lm) infection in mice is a prototypical model for the role of immune deviation in disease resistance. Resistant strains of mice develop a Th1 response to Lm infection, distinguished by secretion of IL-12 and interferon γ. In contrast, susceptible strains display sustained IL-4 expression characteristic of a Th2 response. However, when mechanisms of cell death are blocked, mice display a susceptible phenotype even in the presence of a strong Th1 response, suggesting that cell death, and not cytokine bias, may be an importnt factor in disease resistance. Here, we investigated this hypothesis by comparing lymphocyte cellularity, cell death and Fas expression in resistant CBA and susceptible BALB/c mice during the course of Lm infection. We found that delayed onset of cell death and late Fas induction correlated with massive lymphocyte accumulation and susceptibility to leishmaniasis, while early cell death and rapid Fas induction occurred in resistant mice.
