Novel insight into metabolic reprogrammming in cancer radioresistance: A promising therapeutic target in radiotherapy.
Novel insight into metabolic reprogrammming in cancer radioresistance: A promising therapeutic target in radiotherapy.
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DOI：
10.7150/ijbs.79928
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发表时间：
2023
影响因子：
9.2
通讯作者：
Fan X
中科院分区：
文献类型：
--
作者：
Yu Y;Yu J;Ge S;Su Y;Fan X
目前，癌症治疗主要包括手术、放疗、化疗、免疫治疗和分子靶向治疗，其中放疗是主要支柱之一。然而，放射抗性的发生在很大程度上限制了其治疗效果。代谢重编程是癌症进展和治疗抗性的重要标志。在放射治疗中，DNA断裂是细胞损伤的主要机制，反过来，癌细胞容易增加葡萄糖、谷氨酰胺、丝氨酸、精氨酸、脂肪酸等的代谢通量，从而为DNA损伤修复提供足够的底物和能量。因此，研究代谢重编程与肿瘤放射抵抗之间的联系，可能为提高肿瘤治疗疗效提供新思路。本文主要综述了糖、氨基酸、脂类、核苷酸等代谢改变在肿瘤放射抵抗中的作用，并提出了可能的治疗靶点，以提高肿瘤放射治疗的疗效。
Currently, cancer treatment mainly consists of surgery, radiotherapy, chemotherapy, immunotherapy, and molecular targeted therapy, of which radiotherapy is one of the major pillars. However, the occurrence of radioresistance largely limits its therapeutic effect. Metabolic reprogramming is an important hallmark in cancer progression and treatment resistance. In radiotherapy, DNA breakage is the major mechanism of cell damage, and in turn, cancer cells are prone to increase the metabolic flux of glucose, glutamine, serine, arginine, fatty acids etc., thus providing sufficient substrates and energy for DNA damage repair. Therefore, studying the linkage between metabolic reprogramming and cancer radioresistance may provide new ideas for improving the efficacy of tumor therapy. This review mainly focuses on the role of metabolic alterations, including glucose, amino acid, lipid, nucleotide and other ion metabolism, in radioresistance, and proposes possible therapeutic targets to improve the efficacy of cancer radiotherapy.
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影响因子：
5.7
作者：
Bola BM;Chadwick AL;Michopoulos F;Blount KG;Telfer BA;Williams KJ;Smith PD;Critchlow SE;Stratford IJ
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