Analytical determination of bisphenol A (BPA) and bisphenol analogues in paper products by GC-MS/MS
Analytical determination of bisphenol A (BPA) and bisphenol analogues in paper products by GC-MS/MS
复制标题
DOI：
10.1080/19440049.2017.1319076
复制
发表时间：
2017-01-01
影响因子：
2.9
通讯作者：
Leitner, E.
中科院分区：
文献类型：
--
作者：
Jurek, A.;Leitner, E.
双酚A（BPA）; 4-[2-（4-羟基苯基）丙-2-基]苯酚）是一种疑似内分泌干扰物，具有弱雌激素活性，用于各种消费品，包括由纸和纸板产品制成的食品接触材料。由于BPA的使用受到限制，因为其潜在的健康风险，BPA正逐渐被其他双酚所取代，因为这些物质不存在限制。建立了气相色谱-串联质谱（GC-MS/MS）同时测定纸和纸板制品中双酚A、双酚AF（BPAF）、双酚B（BPB）、双酚E（BPE）、双酚F（BPF）和双酚S（BPS）的方法。采用液体萃取法和Folch萃取法对纸张样品进行萃取，并用N，O-双（三甲基硅基）三氟乙酰胺（BSTFA）衍生化，比较两种方法的结果。该方法具有良好的线性（R-2>0.9965）和精密度，重现性和重复性的相对标准偏差（RSD）分别小于16.6%和19.8%。不同双酚的检测限和定量限分别为0.23 - 2.70 μ g/kg（-1）纸和0.78 - 9.10 μ g/kg（-1）纸。不同的纸产品（回收，原生纤维）的分析表明，所有分析的双酚存在于样品中，除了BPAF和BPB。假设100%的分析物最大可能迁移到食品中，对最坏情况的计算表明，可以假设分析产品在双酚迁移方面是安全的。
Bisphenol A (BPA; 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol), a suspected endocrine disruptor with a weak estrogenic activity, is used in a variety of consumer products, including food-contact materials made of paper and cardboard products. Due to restrictions on the use of BPA because of its potential health risks, BPA is gradually being replaced by other bisphenols because no limitations exist for these substances. This study presents a method for the simultaneous analysis of BPA, bisphenol AF (BPAF), bisphenol B (BPB), bisphenol E (BPE), bisphenol F (BPF) and bisphenol S (BPS) in paper and board products using gas chromatography-tandem mass spectrometry (GC-MS/MS). Paper samples were extracted by liquid extraction, as well as by Folch extraction, derivatised with N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) and the results compared. The developed method showed good linearity (R-2>0.9965) and precision, yielding relative standard deviations (RSDs) of less than 16.6% for reproducibility and 19.8% for repeatability. The limits of detection and limits of quantification for the different bisphenols ranged from 0.23 to 2.70 mu gkg(-1) paper and from 0.78 to 9.10 mu gkg(-1) paper, respectively. Analysis of different paper products (recycled, virgin fibre) showed that all the analysed bisphenols were present in the samples, except for BPAF and BPB. A calculation of the worst-case' scenario assuming a maximum potential migration of 100% of the analytes into food showed that the analysed products can be assumed to be safe regarding the migration of bisphenols.