COMPUTER-ASSISTED DESIGN OF AN IMPLANTABLE, INTRATHORACIC ARTIFICIAL LUNG
COMPUTER-ASSISTED DESIGN OF AN IMPLANTABLE, INTRATHORACIC ARTIFICIAL LUNG
复制标题
DOI：
10.1111/j.1525-1594.1994.tb03328.x
复制
发表时间：
1994-11-01
影响因子：
2.4
通讯作者：
ANDERSON, RW
中科院分区：
文献类型：
--
作者：
VASLEF, SN;MOCKROS, LF;ANDERSON, RW
利用对流氧气传输的半经验数学模型，设计了一种新型的、低压力损失的植入式人工肺，它可以作为晚期呼吸衰竭患者肺移植的桥梁。描述了与横流中空纤维膜肺的设计有关的传质和流动摩擦关系。人工肺的设计目的是在血流速度高达5 L/分钟的情况下传输超过200毫升/分钟的氧气。紧凑的设计和15毫米汞柱的血液侧压力损失使该装置可以植入左胸腔，而不需要假体血泵。人工肺的外科植入需要建立流入和流出吻合口。氧气将通过外部来源供应。血液特性、操作条件以及经验性确定的传质和流动特性都被指定并输入到计算机程序中，该程序以数值方式求解设计方程。从而获得装置正面面积、血液路径长度和纤维表面积的计算机生成值。这种计算机辅助设计的使用最大限度地减少了对原型设备进行大量试错测试的需要。体外实验结果表明，所建立的数学模型在中空纤维人工肺的设计中具有较高的精度和实用价值。
A semiempirical mathematical model of convective oxygen transport is used to design a new, low pressure loss, implantable artificial lung that could be used as a bridge to lung transplantation in patients with advanced respiratory failure. The mass transfer and flow friction relations pertinent to the design of a cross-flow hollow fiber membrane lung are described. The artificial lung is designed to transfer over 200 ml/min of oxygen at blood flow rates up to 5 L/min. A compact design and a blood-side pressure loss of < 15 mm Hg allows the device to be implanted in the left chest without the need for a prosthetic blood pump. Surgical implantation of the artificial lung would require the creation of inflow and outflow anastomoses. Oxygen would be supplied via an external source. Blood properties, operating conditions, and empirically determined mass transfer and flow properties are all specified and input into a computer program that numerically solves the design equations. Computer-generated values for the device frontal area, blood path length, and fiber surface area are thereby obtained. The use of this computer-assisted design minimizes the need for extensive trial-and-error testing of prototype devices. Results from in vitro tests of a prototype implantable lung indicate that the mathematical model we describe is an accurate and useful tool in the design of hollow fiber artificial lungs.