IL-17 cytokine family
IL-17 cytokine family
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DOI：
10.1016/j.jaci.2004.10.019
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发表时间：
2004-12-01
影响因子：
14.2
通讯作者：
Huang, SK
中科院分区：
文献类型：
--
作者：
Kawaguchi, M;Adachi, M;Huang, SK
最近定义了一个新的细胞因子家族IL-17，揭示了一个独特的配体-受体信号传导系统。功能研究已经为它在免疫反应调节中的重要性提供了证据。值得注意的是，IL-17 A、IL-17 E（IL-25）和IL-17 F这3个成员在体外和体内都得到了最好的表征，并且已经显示其本质上是促炎性的。这种促炎活性通过它们参与肺部炎症反应来例证，其中IL-17 A和IL-17 F都参与中性粒细胞的募集，并且IL-17 E能够诱导T（H）2细胞因子产生和嗜酸性粒细胞增多。虽然详细的作用机制的阐明仍然是一个活跃的研究领域，但有效的炎症活性及其与各种人类疾病状态的相关性表明这种新的细胞因子家族是人类疾病状况，特别是肺部疾病的病理生理学的重要贡献者。
A new family of cytokines, IL-17, has recently been defined that reveals a distinct ligand-receptor signaling system. Functional studies have provided evidence for its importance in the regulation of immune responses. Notably, 3 members, IL-17A, IL-17E (IL-25), and IL-17F, have been best characterized both in vitro and in vivo, and have been shown to be proinflammatory in nature. This proinflammatory activity is exemplified by their involvement in pulmonary inflammatory responses, in which both IL-17A and IL-17F are involved in the recruitment of neutrophils, and IL-17E is able to induce T(H)2 cytokine production and eosinophilia. Although the elucidation of a detailed mechanism of action continues to be an active area of research, the potent inflammatory activity and its association with various human disease states suggest this new cytokine family as an important contributor to the pathophysiology of human disease conditions, in particular the pulmonary diseases.