Intranasal insulin reduces body fat in men but not in women
Intranasal insulin reduces body fat in men but not in women
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DOI：
10.2337/diabetes.53.11.3024
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发表时间：
2004-11-01
期刊：
影响因子：
7.7
通讯作者：
Kern, W
中科院分区：
文献类型：
--
作者：
Hallschmid, M;Benedict, C;Kern, W
胰岛素作用于中枢神经系统，减少食物摄入量和体重，被认为是主要的肥胖信号。在鼻腔给药后，胰岛素进入脑脊液隔室，在没有实质性吸收进入血流的情况下改变大脑功能。在这里，我们报告了两组健康受试者(每组12名男性和8名女性)8周鼻腔注射胰岛素(4x40IU/天)或安慰剂的效果。接受胰岛素治疗的男性体重减少了1.28公斤，脂肪减少了1.38公斤，腰围减少了1.63厘米。血浆瘦素水平平均下降27%。相比之下，接受胰岛素治疗的女性并没有减少体脂，由于细胞外水分的增加，体重增加了1.04公斤。我们的结果首次在人类中提供了一个强有力的证实，即胰岛素在调节肥胖方面扮演着负反馈信号的角色，并指出了对基于性别的胰岛素分解代谢效应的不同敏感性。
Insulin acts in the central nervous system to reduce food intake and body weight and is considered a major adiposity signal. After intranasal administration, insulin enters the cerebrospinal fluid compartment and alters brain functions in the absence of substantial absorption into the blood stream. Here we report the effects of 8 weeks of intranasal administration of insulin (4 x 40 IU/day) or placebo to two groups of healthy human subjects (12 men and 8 women in each group). The insulin-treated men lost 1.28 kg body wt and 1.38 kg of body fat, and their waist circumference decreased by 1.63 cm. Plasma leptin levels dropped by an average of 27%. In contrast, the insulin-treated women did not lose body fat and gained 1.04 kg body wt due to a rise in extracellular water. Our results provide a strong, first confirmation in humans that insulin acts as a negative feedback signal in the regulation of adiposity and point to a differential sensitivity to the catabolic effects of insulin based on sex.