Role of pattern-recognition receptors in cardiovascular health and disease
Role of pattern-recognition receptors in cardiovascular health and disease
复制标题
DOI：
10.1042/bst0351449
复制
发表时间：
2007-12-01
影响因子：
3.9
通讯作者：
Paul-Clark, M.
中科院分区：
文献类型：
--
作者：
Mitchell, J. A.;Ryffel, B.;Paul-Clark, M.
模式识别受体(PRRs)在免疫细胞功能中的作用现在已经得到了充分的证实。在巨噬细胞和其他免疫细胞中，Toll样受体和胞浆NLRs的激活导致基因的诱导和免疫调节激素的释放，包括细胞因子和一氧化氮(NO)。除了免疫细胞外，心血管系统的结构细胞，包括内皮细胞、血管平滑肌和心肌细胞，也表达功能性PRRs和正义PAMPs(病原体相关分子模式)。此外，细菌和PAMP还能激活凝血系统和血小板。TLRs现在与一系列心血管疾病和综合征有关，包括动脉粥样硬化和脓毒症。我们的团队正在研究这样的假设，即心血管系统的组织，包括血管、内皮、心脏和血液，感觉病原体与免疫细胞(主要是巨噬细胞)相比如何存在差异，识别这些差异将揭示心血管疾病治疗的新靶点。我们已经确定了心血管组织和巨噬细胞如何感知PAMP的相似和不同之处的例子。这些发现将与我们对这些信息如何导致新治疗的解释一起讨论。
A role for PRRs (pattern-recognition receptors) in immune cell function is now well established. In macrophages and other immune cells, activation of TLRs (Toll-like receptors) and cytosolic NLRs [NOD (nucleotide oligomerization domain) proteins containing a leucine-rich repeat] results in the induction of genes and release of imunoregulator hormones including cytokines and NO (nitric oxide). In addition to immune cells, structural cells of the cardiovascular system including endothelial cells, vascular smooth muscle and cardiac myocytes express functional PRRs and sense PAMPs (pathogen-associated molecular patterns). Furthermore, bacteria and PAMPs activate the coagulation system and platelets. TLRs are now implicated in a range of cardiovascular diseases and syndromes including atherosclerosis and sepsis. our group is working on the hypotheses that differences exist in how tissues of the cardiovascular system, including vessels, endothelium, heart and blood, sense pathogens compared with immune cells (principally macrophages) and that identifying such differences will reveal new therapeutic targets for the treatment of cardiovascular disease. We have identified examples of similarities and differences in how cardiovascular tissues and macrophages sense PAMPs. These findings will be discussed together with our interpretation of how this information may lead to new treatments.