Estrogen rapidly induces the phosphorylation of the cAMP response element binding protein in rat brain.
Estrogen rapidly induces the phosphorylation of the cAMP response element binding protein in rat brain.
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DOI：
10.1210/endo.137.5.8612562
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发表时间：
1996-05
期刊：
影响因子：
4.8
通讯作者：
Yue Zhou;J. Watters;D. Dorsa
中科院分区：
文献类型：
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作者：
Yue Zhou;J. Watters;D. Dorsa
雌激素治疗卵巢切除大鼠迅速增加的cAMP反应元件结合蛋白（CREB）的磷酸化形式的神经元的视前区和床核的终纹的免疫反应性。这些影响在雌激素暴露后15分钟内检测到。由于用于这些研究的抗血清检测CREB磷酸化ser133，这是重要的转录激活这些数据提供了一个可能的解释雌激素对神经元基因缺乏雌激素反应元件（ERE），但含有cAMP反应元件（克雷斯）的影响。这些数据还提供了类固醇激素的非基因组效应的证据，涉及蛋白激酶相关的信号转导途径，传统上与细胞膜上的效应相关。
Estrogen treatment of ovariectomized rats rapidly increases immunoreactivity for the phosphorylated form of the cAMP response element binding protein (CREB)in neurons of the preoptic area and the bed nucleus of the stria terminalis. These effects were detected within 15 minutes after estrogen exposure. Since the antisera used for these studies detect CREB phosphorylation at ser133, which is important for transcriptional activation these data provide a possible explanation for estrogen's effects on neuronal genes lacking estrogen response elements (EREs) but which contain cAMP response elements (CREs). These data also provide evidence for non-genomic effects of steroid hormones involving protein kinase associated signal transduction pathways traditionally associated with effects at the cell membrane.