PET 18F-flurpridaz quantitative measurements of myocardial blood flow: Added value for diagnosis of coronary artery disease? Of course!
PET 18F-flurpridaz quantitative measurements of myocardial blood flow: Added value for diagnosis of coronary artery disease? Of course!
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PET 18F-flupridaz 定量测量心肌血流量：对诊断冠状动脉疾病的附加值？
DOI：
10.1007/s12350-020-02043-1
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发表时间：
2020
影响因子：
2.4
通讯作者：
H. Gewirtz
中科院分区：
文献类型：
--
作者：
H. Gewirtz
在最新一期的杂志中，Moody等人报告了对Fflurpiridaz(FPZ)、心肌血流量(MBF)的PET定量测量用于诊断冠状动脉疾病(CAD)的回顾分析结果。患者(n=231)临床稳定，选自参加flurpridaz 301试验的较大组(n=755；NCT01347710)。所有参与者都能够接受临床显示的SPECT心肌灌注成像(MPI)的运动或血管扩张剂负荷试验。这项子研究没有预先规定，需要有足够技术质量的动态PET数据来获得定量的PET MBF测量。使用Corridor4DM软件进行PET数据处理和分析(V 2017；INVIA医学成像解决方案，密歇根州安娜堡)。金标准比较器是由有创冠状动脉造影术(ICA；考虑50%和70%标准)确定的定量、直径百分比、狭窄(QCA)。虽然所有患者的ICA信息都可用，但FFR数据不能。数据分析详尽(8个数字和同样全面的表格)，并提供了与文件正文类似的补充数据。因此，社论将只侧重于工作的关键要点以及一些局限性。
In the current issue of the Journal, Moody et al report the results of a retrospective analysis of Fflurpiridaz (FPZ), PET quantitative measurements of myocardial blood flow (MBF) for diagnosis of coronary artery disease (CAD). Patients (n = 231) were clinically stable and selected from a larger group enrolled in the flurpridaz 301 trial (n = 755; NCT01347710). All participants were able to undergo either an exercise or vasodilator stress test for clinically indicated SPECT myocardial perfusion imaging (MPI). The sub-study was not pre-specified and required availability of dynamic PET data of sufficient technical quality to obtain quantitative PET MBF measurements. PET data processing and analysis was performed using Corridor4DM software (V 2017; INVIA Medical Imaging Solutions, Ann Arbor, MI). The gold standard comparator was quantitative, percent diameter, stenosis (QCA) as determined from invasive coronary angiography (ICA; 50% and 70% criteria considered). While ICA information was available on all patients, FFR data were not. The data analysis was exhaustive (8 figures and as many equally comprehensive tables) with similar supplemental data submitted as that in the body of the paper. Accordingly, the editorial will to focus only on key highlights as well as some limitations of the work.
影响因子：
20.1
作者：
Deyell MW;Krahn AD;Goldberger JJ
通讯作者：
Goldberger JJ