Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament
Genetic influence on variability in human acute experimental pain sensitivity associated with gender, ethnicity and psychological temperament
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DOI：
10.1016/j.pain.2004.02.027
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发表时间：
2004-06-01
期刊：
影响因子：
7.4
通讯作者：
Dionne, RA
中科院分区：
文献类型：
--
作者：
Kim, HS;Neubert, JK;Dionne, RA
虽然各种文化、心理和生理因素都会导致临床和实验环境中的变异，但遗传因素在人类疼痛敏感性中的作用越来越被认为是一个重要因素。这项研究的目的是评估遗传对与性别、种族和气质相关的人类疼痛敏感性变异的影响。通过视觉模拟量表评级测量对实验性疼痛热刺激和冷刺激的疼痛敏感性，并评估人格的气质维度。使用 5' 核酸酶测定对香草酸受体 I 亚型基因 (TRPV1)、δ 阿片受体 I 亚型基因 (OPRD2) 和儿茶酚 O-甲基转移酶基因 (COMT) 中的基因座进行基因分型。共有 500 名正常参与者（306 名女性和 194 名男性）接受了评估。样本构成为 62.0% 欧洲裔美国人、17.4% 非裔美国人、9.0% 亚裔美国人和 8.6% 西班牙裔美国人，以及 3.0% 混血儿。根据分类和回归树 (CART) 分析，携带 TRPV1 Val(585) Val 等位基因的欧洲裔美国人女性和伤害规避程度较低的男性表现出较长的冷戒断时间。 CART 确定性别、OPRD1 多态性和性格气质维度是 49 摄氏度热痛敏感性的主要决定因素。我们的观察表明，性别、种族和气质通过与 TRPV1 和 OPRD1 单核苷酸多态性的相互作用导致热痛和冷痛敏感性的个体差异。 (C) 2004 年由 Elsevier B.V. 代表国际疼痛研究协会出版。
While a variety of cultural, psychological and physiological factors contribute to variability in both clinical and experimental contexts, the role of genetic factors in human pain sensitivity is increasingly recognized as an important element. This study was performed to evaluate genetic influences on variability in human pain sensitivity associated with gender, ethnicity and temperament. Pain sensitivity in response to experimental painful thermal and cold stimuli was measured with visual analogue scale ratings and temperament dimensions of personality were evaluated. Loci in the vanilloid receptor subtype I gene (TRPV1), delta opioid receptor subtype I gene (OPRD2) and catechol O-methyltransferase gene (COMT) were genotyped using 5' nuclease assays. A total of 500 normal participants (306 females and 194 males) were evaluated. The sample composition was 62.0% European American, 17.4% African American, 9.0% Asian American, and 8.6% Hispanic, and 3.0% individuals with mixed racial parentage. Female European Americans with the TRPV1 Val(585) Val allele and males with low harm avoidance showed longer cold withdrawal times based on the classification and regression tree (CART) analysis. CART identified gender, an OPRD1 polymorphism and temperament dimensions of personality as the primary determinants of heat pain sensitivity at 49 degreesC. Our observations demonstrate that gender, ethnicity and temperament contribute to individual variation in thermal and cold pain sensitivity by interactions with TRPV1 and OPRD1 single nucleotide polymorphisms. (C) 2004 Published by Elsevier B.V. on behalf of International Association for the Study of Pain.