The Role of Suppression in Amblyopia
The Role of Suppression in Amblyopia
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DOI：
10.1167/iovs.11-7233
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发表时间：
2011-06-01
影响因子：
4.4
通讯作者：
Hess, Robert F.
中科院分区：
文献类型：
--
作者：
Li, Jingrong;Thompson, Benjamin;Hess, Robert F.
目的.本研究有三个主要目的：评估斜视、屈光参差和混合性弱视患者的抑制程度;建立抑制与弱视程度之间的关系;比较样本中临床亚组的抑制程度。使用两种标准的抑制措施（Bagolini镜片和中性密度[ND]过滤器，Worth 4-Dot测试）和一种新的方法，包括在可变的眼间对比度的条件下测量分视运动阈值，对43例伴有斜视、屈光参差或两者结合的弱视患者的抑制程度进行了量化。用新的双视运动阈值技术进行的抑制定量测量与用标准临床技术（Bagolini镜片和ND滤光片，Worth 4-Dot测试）进行的测量之间具有良好的一致性。在我们的临床样本中，发现抑制程度与弱视程度直接相关，其中较强的抑制与眼间视力和较差的立体视力的较大差异相关。抑制与斜视的类型或角度无关（当存在斜视时）或既往治疗史。这些结果表明，抑制可能在弱视综合征中起主要作用，因此对弱视的治疗有意义。（Invest Ophthalmol维斯科学。2011;52：4169-4176）DOI：10.1167/iovs.11-7233
PURPOSE. This study had three main goals: to assess the degree of suppression in patients with strabismic, anisometropic, and mixed amblyopia; to establish the relationship between suppression and the degree of amblyopia; and to compare the degree of suppression across the clinical subgroups within the sample.METHODS. Using both standard measures of suppression (Bagolini lenses and neutral density [ND] filters, Worth 4-Dot test) and a new approach involving the measurement of dichoptic motion thresholds under conditions of variable interocular contrast, the degree of suppression in 43 amblyopic patients with strabismus, anisometropia, or a combination of both was quantified.RESULTS. There was good agreement between the quantitative measures of suppression made with the new dichoptic motion threshold technique and measurements made with standard clinical techniques (Bagolini lenses and ND filters, Worth 4-Dot test). The degree of suppression was found to correlate directly with the degree of amblyopia within our clinical sample, whereby stronger suppression was associated with a greater difference in interocular acuity and poorer stereoacuity. Suppression was not related to the type or angle of strabismus when this was present or the previous treatment history.CONCLUSIONS. These results suggest that suppression may have a primary role in the amblyopia syndrome and therefore have implications for the treatment of amblyopia. (Invest Ophthalmol Vis Sci. 2011;52:4169-4176) DOI:10.1167/iovs.11-7233