Reflections on effects of low doses and risk inference based on the UNSCEAR 2021 report on ‘biological mechanisms relevant for the inference of cancer risks from low-dose and low-dose-rate radiation’
Reflections on effects of low doses and risk inference based on the UNSCEAR 2021 report on ‘biological mechanisms relevant for the inference of cancer risks from low-dose and low-dose-rate radiation’
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基于 UNSCEAR 2021 年报告“与低剂量和低剂量率辐射推断癌症风险相关的生物机制”对低剂量影响和风险推断的思考
DOI：
10.1088/1361-6498/ac591c
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发表时间：
2022
影响因子：
1.5
通讯作者：
A. Wojcik
中科院分区：
文献类型：
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作者：
A. Wojcik
2021年联合国原子辐射影响问题科学委员会（UNSCIONAL）的报告总结了低剂量辐射作用的生物机制，由于流行病学调查的统计能力较低，必须推断癌症风险水平。这是自1994年以来第四份联合国辐射科委会报告，该报告探讨了低剂量照射后的生物效应，目的是审查这些效应是否支持辐射诱发癌症的线性非阈值剂量反应假设。所有四份报告的结论都是肯定的。2021年报告的新方面是，它关注癌症风险推断的过程。本文的目的是讨论有关LNT的结论的后果和从生物学研究中推断风险的可能性。
The 2021 United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) report summarises the knowledge on biological mechanisms of radiation action at low doses where, due to low statistical power of epidemiological investigations, the level of cancer risk must be inferred. It is the fourth UNSCEAR report since 1994 that looks into biological effects following low dose exposure with the aim of examining whether they support the assumption of the linear non-threshold (LNT) dose response for radiation-induced cancers. The conclusions of all four reports are affirmative. The new aspect of the 2021 report is that it focuses on the process of cancer risk inference. The aim of this article is to discuss the consequences of the conclusions regarding LNT and the possibilities of inferring risks from biological studies.
非靶向效应是否会增加或减少与线性非阈值（LNT）模型有关的低剂量风险？
DOI：
10.1016/j.mrfmmm.2010.01.008
发表时间：
2010-05-01
影响因子：
2.3
作者：
Little, M. P.
通讯作者：
Little, M. P.