Indomethacin treatment of rats with dimethylhydrazine-induced intestinal tumors.
Indomethacin treatment of rats with dimethylhydrazine-induced intestinal tumors.
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吲哚美辛治疗二甲肼诱导的肠道肿瘤大鼠。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
Luckert Ph
中科院分区：
文献类型：
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作者：
Morris Pollard;Luckert Ph
在通过管饲法给予5周剂量的1，2-二甲基肼（DMH）后，在雄性Sprague-Dawley大鼠中诱导肠肿瘤。在此之后的间隔，各组大鼠给予吲哚美辛（IND）的饮用水。在三项试验中，与未接受IND的对照组大鼠相比，大鼠肿瘤发生率显著降低了40%，体重无显著差异。此外，在发生肿瘤的IND治疗大鼠中，与对照大鼠相比，肿瘤的数量和大小通常较小。一组DMH处理的大鼠经灌胃给予IND粗品，与未处理的对照组大鼠之间的差异不显著。很可能治疗是针对肿瘤而不是诱导肿瘤的DMH。
Intestinal tumors were induced in male Sprague-Dawley rats following the administration of five weekly doses of 1,2-dimethylhydrazine (DMH) by gavage. At intervals thereafter, groups of rats were given indomethacin (IND) in the drinking water. In three trials, the incidence of rats with tumors was significantly reduced by 40% below the control rats which did not receive IND and there was no significant difference in body weights. Also, in those IND-treated rats which developed tumors, the tumors were generally smaller in numbers and sizes compared to the control rats. A group of DMH-treated rats was treated with crude IND by gavage and the differences between them and untreated control rats were not significant. It is likely that the treatment was directed at the tumors and not at the DMH which induced them.