Value of combining serum carcinoembryonic antigen and PET/CT in predicting EGFR mutation in non-small cell lung cancer
Value of combining serum carcinoembryonic antigen and PET/CT in predicting EGFR mutation in non-small cell lung cancer
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DOI：
10.21037/jtd.2017.12.143
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发表时间：
2018-02-01
影响因子：
2.5
通讯作者：
Zhou, Yanbin
中科院分区：
文献类型：
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作者：
Gu, Jincui;Xu, Siqi;Zhou, Yanbin
背景：探讨非小细胞肺癌(NSCLC)患者治疗前血清癌胚抗原(CEA)水平、原发灶对F-18-脱氧葡萄糖(F-18-FDG)摄取值与表皮生长因子受体(EGFR)突变状态的关系。方法：对210例NSCLC患者在抗肿瘤治疗前进行EGFR突变检测和F-18-FDG正电子发射计算机断层扫描(PET/CT)检查。分析EGFR基因突变与患者临床特征、血清CEA、PET/CT影像特征、原发灶最大标准摄取值(SUVmax)的关系。用受试者-操作特征(ROC)曲线评估这些因素的预测价值。结果：70例患者(33.3%)发现EGFR突变。高CEA组(CEA>；=7.0 ng/mL)较低CEA组(CEA<；7.0 ng/mL)更易发生EGFR突变(40.4%vs.27.6%；P=0.05)。女性(P
Background: We sought to investigate the associations between pretreatment serum Carcinoembryonic antigen (CEA) level, F-18-Fluoro-2-deoxyglucose (F-18-FDG) uptake value of primary tumor and epidermal growth factor receptor (EGFR) mutation status in non-small cell lung cancer (NSCLC).Methods: We retrospectively reviewed medical records of 210 NSCLC patients who underwent EGFR mutation test and F-18-FDG positron emission tomography/computed tomography (PET/CT) scan before antitumor therapy. The associations between EGFR mutations and patients' characteristics, serum CEA, PET/CT imaging characteristics maximal standard uptake value (SUVmax) of the primary tumor were analyzed. Receiver-operating characteristic (ROC) curve was used to assess the predictive value of these factors.Results: EGFR mutations were found in 70 patients (33.3%). EGFR mutations were more common in high CEA group (CEA >= 7.0 ng/mL) than in low CEA group (CEA < 7.0 ng/mL) (40.4% vs. 27.6%; P=0.05). Females (P